The Buffalo Bills lost in a regular-season game against the AFC South against the Texans on November 20.
| TEAM | DATE | L | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 11/20/2025 | 1 | @ | L 19-23 | 2 | 14 | 326 | 261 | 31.3 | 60.0 | ||
| 2 | | Bills | 10/6/2024 | 1 | @ | L 20-23 | 2 | 16 | 276 | 425 | 21.4 | 100.0 | ||
| 3 | | Bills | 10/8/2023 | 1 | vs | L 20-25 | 3 | 18 | 388 | 474 | 41.7 | |||
| 4 | | Bills | 11/21/2021 | 1 | vs | L 15-41 | 2 | 19 | 311 | 370 | 50.0 | |||
| 5 | | Bills | 11/7/2021 | 1 | @ | L 6-9 | 0 | 17 | 301 | 218 | 40.0 | 0.0 | ||
| 6 | | Bills | 10/18/2021 | 1 | @ | L 31-34 | 3 | 28 | 417 | 362 | 53.8 | 0.0 | ||
| 7 | | Bills | 10/13/2020 | 1 | @ | L 16-42 | 2 | 23 | 370 | 334 | 76.5 | |||
| 8 | | Bills | 10/21/2018 | 1 | @ | L 5-37 | 0 | 15 | 303 | 376 | 22.2 | 0.0 | ||
| 9 | | Bills | 10/14/2018 | 1 | @ | L 13-20 | 1 | 12 | 229 | 216 | 40.0 | |||
| 10 | | Bills | 10/25/2015 | 1 | @ | L 31-34 | 3 | 26 | 375 | 295 | 25.0 | 0.0 | ||
| 11 | | Bills | 9/28/2014 | 1 | @ | L 17-23 | 2 | 17 | 316 | 301 | 31.3 | |||
| 12 | | Bills | 11/25/2012 | 1 | @ | L 13-20 | 1 | 16 | 304 | 312 | 30.8 | |||
| 13 | | Bills | 11/4/2012 | 1 | @ | L 9-21 | 0 | 17 | 304 | 374 | 18.2 | 100.0 | ||
| 14 | | Bills | 10/21/2012 | 1 | vs | L 34-35 | 4 | 22 | 382 | 390 | 58.3 | 0.0 | ||
| 15 | | Bills | 12/4/2011 | 1 | vs | L 17-23 | 2 | 18 | 386 | 317 | 43.8 | 50.0 | ||
| 16 | | Bills | 10/10/2010 | 1 | vs | L 26-36 | 3 | 17 | 306 | 381 | 27.3 | 0.0 | ||
| 17 | | Bills | 11/22/2009 | 1 | @ | L 15-18 | 1 | 14 | 343 | 310 | 27.3 | 0.0 | ||
| 18 | | Bills | 11/15/2009 | 1 | @ | L 17-41 | 2 | 14 | 296 | 378 | 35.7 | 0.0 | ||
| 19 | | Bills | 11/1/2009 | 1 | vs | L 10-31 | 1 | 9 | 204 | 439 | 20.0 | 0.0 | ||
| 20 | | Bills | 11/25/2007 | 1 | @ | L 14-36 | 2 | 20 | 297 | 416 | 56.3 | 50.0 | ||
| 21 | | Bills | 12/24/2006 | 1 | vs | L 29-30 | 2 | 22 | 368 | 396 | 20.0 | 50.0 | ||
| 22 | | Bills | 11/12/2006 | 1 | @ | L 16-17 | 1 | 10 | 162 | 384 | 35.7 | 100.0 | ||
| 23 | | Bills | 9/12/2004 | 1 | vs | L 10-13 | 1 | 16 | 242 | 225 | 50.0 | |||
| 24 | | Bills | 12/14/2003 | 1 | @ | L 26-28 | 3 | 13 | 241 | 349 | 16.7 | 100.0 | ||
| 25 | | Bills | 11/23/2003 | 1 | vs | L 14-17 | 2 | 16 | 228 | 326 | 23.1 | 100.0 | ||
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More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |