Between the 2000 and 2020 seasons, Fred Jackson rushed for the most yards by a Bills running back, with 5,646 yards.
| NAME | RUSH YDS | GP | ATT | YPC | RUSH YDS/G | RUSH TD | REC YDS | REC | TRG | AVG | REC YDS/G | REC TD | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | F. Jackson | 5,646 | 106 | 1,279 | 4.4 | 53.3 | 30 | 2,640 | 322 | 437 | 8.2 | 24.9 | 7 |
| 2 | | T. Henry | 3,849 | 54 | 963 | 4.0 | 71.3 | 27 | 691 | 103 | 140 | 6.7 | 12.8 | 2 |
| 3 |  | L. McCoy | 3,814 | 57 | 885 | 4.3 | 66.9 | 25 | 1,334 | 175 | 230 | 7.6 | 23.4 | 5 |
| 4 | | W. McGahee | 3,365 | 46 | 868 | 3.9 | 73.2 | 24 | 503 | 68 | 101 | 7.4 | 10.9 | 0 |
| 5 | | C.J. Spiller | 3,321 | 70 | 668 | 5.0 | 47.4 | 12 | 1,195 | 158 | 202 | 7.6 | 17.1 | 6 |
| 6 |  | M. Lynch | 2,765 | 45 | 687 | 4.0 | 61.4 | 17 | 670 | 94 | 131 | 7.1 | 14.9 | 1 |
| 7 |  | D. Singletary | 1,462 | 28 | 307 | 4.8 | 52.2 | 4 | 463 | 67 | 91 | 6.9 | 16.5 | 2 |
| 8 | | S. Bryson | 967 | 37 | 254 | 3.8 | 26.1 | 2 | 339 | 42 | 60 | 8.1 | 9.2 | 2 |
| 9 | | M. Gillislee | 844 | 20 | 148 | 5.7 | 42.2 | 11 | 79 | 15 | 18 | 5.3 | 4.0 | 1 |
| 10 |  | F. Gore | 599 | 16 | 166 | 3.6 | 37.4 | 2 | 100 | 13 | 16 | 7.7 | 6.3 | 0 |
| 11 | | K. Williams | 517 | 11 | 93 | 5.6 | 47.0 | 7 | 96 | 11 | 14 | 8.7 | 8.7 | 2 |
| 12 | | S. Morris | 488 | 53 | 134 | 3.6 | 9.2 | 6 | 452 | 61 | 78 | 7.4 | 8.5 | 1 |
| 13 |  | Z. Moss | 481 | 13 | 112 | 4.3 | 37.0 | 4 | 95 | 14 | 18 | 6.8 | 7.3 | 1 |
| 14 | | A. Dixon | 476 | 32 | 126 | 3.8 | 14.9 | 3 | 93 | 14 | 16 | 6.6 | 2.9 | 0 |
| 15 | | A. Thomas | 467 | 26 | 143 | 3.3 | 18.0 | 2 | 234 | 37 | 45 | 6.3 | 9.0 | 1 |
| 16 | | T. Choice | 389 | 30 | 105 | 3.7 | 13.0 | 2 | 70 | 15 | 32 | 4.7 | 2.3 | 0 |
| 17 | | C. Ivory | 385 | 13 | 115 | 3.3 | 29.6 | 1 | 205 | 13 | 21 | 15.8 | 15.8 | 0 |
| 18 | | A. Smith | 354 | 11 | 101 | 3.5 | 32.2 | 4 | 20 | 3 | 5 | 6.7 | 1.8 | 0 |
| 19 | | S. Williams | 330 | 25 | 89 | 3.7 | 13.2 | 2 | 137 | 20 | 26 | 6.9 | 5.5 | 0 |
| 20 | | M. Murphy | 291 | 12 | 59 | 4.9 | 24.3 | 0 | 33 | 13 | 21 | 2.5 | 2.8 | 0 |
| 21 | | M. Tolbert | 247 | 12 | 66 | 3.7 | 20.6 | 1 | 78 | 14 | 17 | 5.6 | 6.5 | 0 |
| 22 | | L. Centers | 216 | 32 | 45 | 4.8 | 6.8 | 4 | 1,008 | 123 | 168 | 8.2 | 31.5 | 2 |
| 23 | | J. Burns | 193 | 58 | 64 | 3.0 | 3.3 | 0 | 88 | 9 | 13 | 9.8 | 1.5 | 1 |
| 24 | | T.J. Yeldon | 133 | 9 | 27 | 4.9 | 14.8 | 0 | 146 | 14 | 19 | 10.4 | 16.2 | 1 |
| 25 | | B. Brown | 126 | 7 | 36 | 3.5 | 18.0 | 0 | 176 | 16 | 25 | 11.0 | 25.1 | 0 |
StatMuse has season-level data for rushing yards going back to the 1932 season.
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More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |