| TEAM | OPPONENT | WEEK/ROUND | DATE | TIME (ET) | SPREAD | OVER/UNDER | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Buffalo Bills | -114 | @ | -105 | WK 1 | Sun, Sep 13, 2026 | 1:00 PM | -1.5 | 44.5 | |
| 2 | | Buffalo Bills | -162 | vs | +137 | WK 2 | Thu, Sep 17, 2026 | 8:15 PM | -3.0 | 52.5 | |
| 3 | | Buffalo Bills | -154 | vs | +127 | WK 3 | Sun, Sep 27, 2026 | 1:00 PM | -2.5 | 48.5 | |
| 4 | | Buffalo Bills | -179 | vs | +148 | WK 4 | Sun, Oct 4, 2026 | 1:00 PM | -3.0 | 49.5 | |
| 5 | | Buffalo Bills | +160 | @ | -193 | WK 5 | Mon, Oct 12, 2026 | 8:15 PM | +3.0 | 53.5 | |
| 6 | | Buffalo Bills | -151 | vs | +129 | WK 12 | Thu, Nov 26, 2026 | 8:20 PM | -2.5 | 50.5 | |
| 7 | | Buffalo Bills | -125 | @ | +105 | WK 16 | Fri, Dec 25, 2026 | 4:30 PM | -1.5 | 46.5 |
Betting lines shown represent consensus, closing odds.
More NFL News
Former Buffalo Bills quarterback Jim Kelly says he was hospitalized after a stroke in the spring
Falcons agree to $54 million, 3-year deal that makes Kyle Pitts Sr. 1 of NFL's top paid tight ends
Bills owner Terry Pegula helps open team's new $2.1 billion stadium
Brendan Sorsby has to wait until 2027 to join the NFL
Jeffery Simmons cashes in on big season by signing record-setting, 3-year deal with Titans
Dexter Lawrence looking to keep same offseason approach before reporting to Bengals' training camp
More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |