The Buffalo Bills have a record of 5-6 against the AFC South between February 27, 2021 and February 27, 2026.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 10/3/2021 | 1-0 | vs | W 40-0 | 1.000 | 4 | 26 | 450 | 109 | 41.7 | 50.0 | ||
| 2 | | Bills | 10/18/2021 | 0-1 | @ | L 31-34 | .000 | 3 | 28 | 417 | 362 | 53.8 | 0.0 | ||
| 3 | | Bills | 11/7/2021 | 0-1 | @ | L 6-9 | .000 | 0 | 17 | 301 | 218 | 40.0 | 0.0 | ||
| 4 | | Bills | 11/21/2021 | 0-1 | vs | L 15-41 | .000 | 2 | 19 | 311 | 370 | 50.0 | |||
| 5 | | Bills | 9/19/2022 | 1-0 | vs | W 41-7 | 1.000 | 5 | 23 | 414 | 187 | 38.5 | 66.7 | ||
| 6 | | Bills | 10/8/2023 | 0-1 | vs | L 20-25 | .000 | 3 | 18 | 388 | 474 | 41.7 | |||
| 7 | | Bills | 9/23/2024 | 1-0 | vs | W 47-10 | 1.000 | 6 | 25 | 388 | 239 | 54.5 | 100.0 | ||
| 8 | | Bills | 10/6/2024 | 0-1 | @ | L 20-23 | .000 | 2 | 16 | 276 | 425 | 21.4 | 100.0 | ||
| 9 | | Bills | 10/20/2024 | 1-0 | vs | W 34-10 | 1.000 | 4 | 18 | 389 | 289 | 30.0 | |||
| 10 | | Bills | 11/10/2024 | 1-0 | @ | W 30-20 | 1.000 | 3 | 21 | 415 | 361 | 50.0 | 66.7 | ||
| 11 | | Bills | 11/20/2025 | 0-1 | @ | L 19-23 | .000 | 2 | 14 | 326 | 261 | 31.3 | 60.0 | ||
| Average | .455 | 3.1 | 20.5 | 370.5 | 299.5 | 40.7 | 7.6 | ||||||||
| Total | 5-6 | .455 | 34 | 225 | 4,075 | 3,295 | 40.7 | 61.1 |
More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
