The Buffalo Bills have a 7-9-1 record against the spread as favorites against the NFC at home since 2018.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 12/16/2018 | 0-1 | -145 | vs | +135 | W 14-13 | -2.5 | -1.5 (N) | 39.5 | -12.5 (U) | 2 | 20 | 312 | 313 | 25.0 | 50.0 | ||
| 2 | | Bills | 10/27/2019 | 0-1 | -115 | vs | -105 | L 13-31 | -1 | -19 (N) | 39.5 | +4.5 (O) | 2 | 16 | 253 | 371 | 40.0 | 0.0 | ||
| 3 | | Bills | 11/3/2019 | 1-0 | -568 | vs | +419 | W 24-9 | -10.5 | +4.5 (Y) | 37 | -4 (U) | 3 | 18 | 268 | 243 | 50.0 | 50.0 | ||
| 4 | | Bills | 9/27/2020 | 1-0 | -124 | vs | +105 | W 35-32 | -1.5 | +1.5 (Y) | 46.5 | +20.5 (O) | 5 | 23 | 375 | 478 | 50.0 | 100.0 | ||
| 5 | | Bills | 9/26/2021 | 1-0 | -346 | vs | +270 | W 43-21 | -7 | +15 (Y) | 45.5 | +18.5 (O) | 5 | 29 | 481 | 290 | 60.0 | 0.0 | ||
| 6 | | Bills | 12/19/2021 | 1-0 | -834 | vs | +557 | W 31-14 | -14.5 | +2.5 (Y) | 43 | +2 (O) | 4 | 21 | 312 | 275 | 42.9 | 100.0 | ||
| 7 | | Bills | 1/2/2022 | 0-0-1 | -947 | vs | +625 | W 29-15 | -14 | 0 (P) | 46 | -2 (U) | 4 | 28 | 351 | 265 | 58.3 | 100.0 | ||
| 8 | | Bills | 10/30/2022 | 0-1 | -502 | vs | +381 | W 27-17 | -10.5 | -0.5 (N) | 47 | -3 (U) | 3 | 20 | 369 | 398 | 28.6 | |||
| 9 | | Bills | 11/13/2022 | 0-1 | -274 | vs | +222 | L 30-33 | -6.5 | -9.5 (N) | 46.5 | +16.5 (O) | 3 | 29 | 486 | 481 | 53.8 | 0.0 | ||
| 10 | | Bills | 10/15/2023 | 0-1 | -1216 | vs | +750 | W 14-9 | -15 | -10 (N) | 43.5 | -20.5 (U) | 2 | 22 | 297 | 317 | 50.0 | |||
| 11 | | Bills | 10/26/2023 | 0-1 | -516 | vs | +384 | W 24-18 | -10 | -4 (N) | 43 | -1 (U) | 3 | 25 | 427 | 302 | 53.8 | 0.0 | ||
| 12 | | Bills | 12/17/2023 | 1-0 | -139 | vs | +117 | W 31-10 | -2.5 | +18.5 (Y) | 49 | -8 (U) | 4 | 28 | 351 | 195 | 55.6 | |||
| 13 | | Bills | 9/8/2024 | 0-1 | -308 | vs | +246 | W 34-28 | -6.5 | -0.5 (N) | 45.5 | +16.5 (O) | 4 | 23 | 352 | 270 | 33.3 | 100.0 | ||
| 14 | | Bills | 12/1/2024 | 1-0 | -330 | vs | +265 | W 35-10 | -6.5 | +18.5 (Y) | 45.5 | -0.5 (U) | 5 | 20 | 372 | 239 | 50.0 | 100.0 | ||
| 15 | | Bills | 9/28/2025 | 0-1 | -1389 | vs | +833 | W 31-19 | -14.5 | -2.5 (N) | 48.5 | +1.5 (O) | 4 | 20 | 356 | 298 | 30.0 | 0.0 | ||
| 16 | | Bills | 11/16/2025 | 1-0 | -310 | vs | +248 | W 44-32 | -6.5 | +5.5 (Y) | 46.5 | +29.5 (O) | 6 | 19 | 414 | 367 | 54.5 | 50.0 | ||
| 17 | | Bills | 12/28/2025 | 0-1 | -175 | vs | +147 | L 12-13 | -3.5 | -4.5 (N) | 45.5 | -20.5 (U) | 2 | 20 | 331 | 190 | 40.0 | 66.7 | ||
| Average | 2.6 | 3.6 | 22.4 | 359.2 | 311.3 | 46.3 | 3.7 | |||||||||||||
| Total | 7-9-1 | 61 | 381 | 6,107 | 5,292 | 46.3 | 52.4 |
WASStatMuse has team, game-level data for spread records going back to the 1979 season.
More Bills Stats
Team Leaders 
PASS
556
Allen
RUSH
163
Cook
REC
157
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
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RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
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NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
