The Tampa Bay Buccaneers lost in a regular-season or postseason game against the Bills at home on September 22, 1991.
| TEAM | DATE | L | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Buccaneers | 9/22/1991 | 1 | vs | L 10-17 | 1 | 22 | 303 | 421 | 52.6 | 0.0 | ||
| 2 | | Buccaneers | 9/26/1976 | 1 | vs | L 9-14 | 0 | 15 | 338 | 295 |
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