The Arizona Cardinals are 26-32-2 against the spread against the 49ers since 1970.

	TEAM	DATE	ATS	TM			OPP		RESULT	SPREAD	ATS DIFF	O/U	O/U DIFF	TD	1DWN	OFF	OPP OFF	3DWN%	4DWN%
1	Cardinals	12/2/1979	0-1	STL		vs	SF		W 13-10	-6	-3 (N)	43	-20 (U)	2	16	286	290
2	Cardinals	9/14/1980	0-0-1	STL		@	SF		L 21-24	+3	0 (P)	42	+3 (O)	3	21	342	392
3	Cardinals	11/21/1982	0-1	STL		vs	SF		L 20-31	+4	-7 (N)	36	+15 (O)	2	15	254	448
4	Cardinals	9/18/1983	0-1	STL		vs	SF		L 27-42	+3.5	-11.5 (N)	45.5	+23.5 (O)	3	22	385	527
5	Cardinals	11/9/1986	0-1	STL		@	SF		L 17-43	+11	-15 (N)	40.5	+19.5 (O)	2	22	364	460
6	Cardinals	10/18/1987		STL		@	SF		L 28-34					4	18	324	448
7	Cardinals	11/6/1988	1-0	PHX		vs	SF		W 24-23	+3.5	+4.5 (Y)	45	+2 (O)	3	21	355	357
8	Cardinals	11/17/1991	1-0	PHX		@	SF		L 10-14	+11.5	+7.5 (Y)	32	-8 (U)	1	13	176	257	20.0	0.0
9	Cardinals	11/1/1992	1-0	PHX		vs	SF		W 24-14	+13	+23 (Y)	43.5	-5.5 (U)	3	21	342	330	68.8
10	Cardinals	10/24/1993	0-1	PHX		@	SF		L 14-28	+11.5	-2.5 (N)	43	-1 (U)	2	25	429	428	58.8	66.7
11	Cardinals	9/27/1999	0-1	ARI		vs	SF		L 10-24	+2.5	-11.5 (N)	46	-12 (U)	1	20	250	322	30.8	100.0
12	Cardinals	10/1/2000	0-1	ARI		@	SF		L 20-27	+3.5	-3.5 (N)	47	0 (P)	2	16	365	345	23.1	66.7
13	Cardinals	10/27/2002	0-1	ARI		@	SF		L 28-38	+8	-2 (N)	40.5	+25.5 (O)	4	23	420	357	75.0	100.0
14	Cardinals	12/21/2002	1-0	ARI		vs	SF		L 14-17	+3.5	+0.5 (Y)	41	-10 (U)	2	14	184	358	53.8
15	Cardinals	10/26/2003	1-0	ARI		vs	SF		W 16-13	+7	+10 (Y)	41	-12 (U)	1	18	314	255	40.0
16	Cardinals	12/7/2003	0-1	ARI		@	SF		L 14-50	+10	-26 (N)	41	+23 (O)	2	18	210	496	21.4	66.7
17	Cardinals	10/10/2004	0-1	ARI		@	SF		L 28-31	+1	-2 (N)	36.5	+22.5 (O)	4	19	320	448	35.7	100.0
18	Cardinals	12/12/2004	0-1	ARI		vs	SF		L 28-31	-7	-10 (N)	36	+23 (O)	3	25	374	352	43.8
19	Cardinals	10/2/2005	1-0	ARI		vs	SF		W 31-14	-2.5	+14.5 (Y)	43.5	+1.5 (O)	2	24	463	168	42.1
20	Cardinals	12/4/2005	1-0	ARI		@	SF		W 17-10	-3	+4 (Y)	44.5	-17.5 (U)	1	18	404	220	31.3	0.0
21	Cardinals	9/10/2006	0-1	ARI	-550	vs	SF	+400	W 34-27	-8	-1 (N)	43	+18 (O)	4	23	367	393	50.0
22	Cardinals	12/24/2006	1-0	ARI	+165	@	SF	-185	W 26-20	+4	+10 (Y)	45	+1 (O)	2	21	372	223	50.0	100.0
23	Cardinals	9/10/2007	0-0-1	ARI	+170	@	SF	-195	L 17-20	+3	0 (P)	45	-8 (U)	2	20	261	194	40.0
24	Cardinals	11/25/2007	0-1	ARI	-625	vs	SF	+450	L 31-37	-10.5	-16.5 (N)	37.5	+30.5 (O)	4	25	552	374	28.6	100.0
25	Cardinals	9/7/2008	1-0	ARI	-135	@	SF	+115	W 23-13	-2.5	+7.5 (Y)	41.5	-5.5 (U)	2	18	285	291	31.3	66.7
	Average		0.7											2.3	19.6	338.3	349.7
	Total		26-32-2											143	1,197	20,639	21,333

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StatMuse has team, game-level data for spread records going back to the 1979 season.

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More Cardinals Stats

Team Leaders

PASS

818

Brissett

RUSH

223

Love

REC

258

Wilson

Team Rankings

PPG

21.8

17th

OPP PPG

29.3

29th

RUSH YDS/G

100.5

21st

PASS YDS/G

204.5

22nd

2026 Division Standings

TEAM	W	L	PCT
49ers	4	0	1.000
Seahawks	3	1	.750
Rams	2	2	.500
Cardinals	1	3	.250

Schedule

DATE	MATCHUP			TIME (ET)
Sun 10/11	DET	@	ARI	4:25 PM
Sun 10/18	ARI	@	LAR	4:05 PM
Sun 10/25	DEN	@	ARI	4:05 PM
Sun 11/1	ARI	@	DAL	1:00 PM
Sun 11/8	ARI	@	SEA	4:25 PM

Last Game

Cardinals

1 - 3

Final

Giants

3 - 1

Sun 4 Oct 2026

NFL 2026 Leaders

Pass Yards Leaders

1,268

Young

1,214

Goff

1,203

Shough

Rush Yards Leaders

537

Walker

494

Robinson

421

Cook

Rec Yards Leaders

498

Lamb

491

Olave

481

Smith-Njigba

Pass TD Leaders

11

Purdy

11

Cousins

9

Shough

Rush TD Leaders

7

Allen

7

Henry

6

Taylor

Rec TD Leaders

6

Smith-Njigba

5

St. Brown

4

Watson

QB Rating Leaders

126.2

Purdy

119.6

Jackson

111.2

Lawrence

Sack Leaders

6.0

Rousseau

5.5

Turner

4.5

Anderson

NFL 2026 Rankings

PPG Rankings

31.8

30.5

30.3

29.8

29.5

Opp PPG Rankings

12.8

13.3

16.0

16.3

18.3

19.3

Total Yards Rankings

429.0

417.0

412.0

405.8

395.0

389.3

Rush Yards Rankings

196.3

181.0

162.3

153.5

139.0

137.3

Pass Yards Rankings

317.0

303.5

300.8

300.5

292.8

285.3

Sack Leaders

16.0

15.0

14.0

12.0

NFL Fantasy 2026

Fantasy RB Rankings

98.1

Walker

94

Gibbs

91.4

Robinson

Fantasy WR Rankings

84.7

Smith-Njigba

75.2

Lamb

60.3

St. Brown

Fantasy TE Rankings

48.4

Kittle

39.2

Johnson

36.6

Kelce

Fantasy K Rankings

54

Shrader

52

Reichard

47

McPherson

NFL 2026 Betting

Best Record ATS

4-0

3-1

Worst Record ATS

0-4

0-3-1

1-3

NFL 2026 Standings

NFC East	W	L	T	PCT
Giants	3	1	0	.750
Eagles	2	2	0	.500
Cowboys	2	2	0	.500
Commanders	1	3	0	.250
NFC North	W	L	T	PCT
Vikings	4	0	0	1.000
Bears	3	1	0	.750
Lions	2	2	0	.500
Packers	2	2	0	.500
NFC South	W	L	T	PCT
Panthers	2	2	0	.500
Falcons	2	2	0	.500
Saints	1	3	0	.250
Buccaneers	0	4	0	.000
NFC West	W	L	T	PCT
49ers	4	0	0	1.000
Seahawks	3	1	0	.750
Rams	2	2	0	.500
Cardinals	1	3	0	.250

AFC East	W	L	T	PCT
Bills	3	1	0	.750
Patriots	2	2	0	.500
Jets	1	3	0	.250
Dolphins	0	4	0	.000
AFC North	W	L	T	PCT
Browns	3	1	0	.750
Ravens	3	1	0	.750
Steelers	2	2	0	.500
Bengals	2	2	0	.500
AFC South	W	L	T	PCT
Jaguars	3	1	0	.750
Colts	2	2	0	.500
Titans	0	4	0	.000
Texans	0	4	0	.000
AFC West	W	L	T	PCT
Chiefs	4	0	0	1.000
Raiders	3	1	0	.750
Broncos	2	2	0	.500
Chargers	0	4	0	.000