The New Orleans Saints had the highest spread differential by a team in a game in 2021, with a +38.5-spreads differential versus the Packers on September 12.

highest single game ats differential last season
9/12/2021Saints11/14/2021Patriots10/31/2021Eagles10/24/2021Patriots11/21/2021Colts11/14/2021Cowboys12/26/2021Cowboys9/19/2021Bills12/19/2021Lions11/14/2021Panthers10/24/2021Bengals12/12/2021Chiefs9/12/2021Eagles1/9/2022Jaguars1/2/2022Titans10/24/2021Titans9/12/2021Cardinals11/28/2021Bengals11/7/2021Browns10/17/2021Cardinals1/15/2022Bills12/26/2021Texans+38.5+35.5+35+34+33+32.5+32+31.5+31+31+30.5+29.5+29.5+29+28+28+28+27.5+27+26+25.5+25
TEAMDATETMOPPRESULTSPREADATS DIFFO/UO/U DIFFTD1DWNOFFOPP OFF3DWN%4DWN%
New Orleans SaintsNew Orleans Saints9/12/2021
NONO
+158vs
GBGB
-187
W
38-3
+3.5+38.5 (Y)49.5-8.5 (U)52232222950.0100.0
New England PatriotsNew England Patriots11/14/2021
NENE
-137vs
CLECLE
+116
W
45-7
-2.5+35.5 (Y)44.5+7.5 (O)63045221777.8
Philadelphia EaglesPhiladelphia Eagles10/31/2021
PHIPHI
-170@
DETDET
+144
W
44-6
-3+35 (Y)48+2 (O)52735022850.0
New England PatriotsNew England Patriots10/24/2021
NENE
-334vs
NYJNYJ
+262
W
54-13
-7+34 (Y)42.5+24.5 (O)73255129958.3100.0
Indianapolis ColtsIndianapolis Colts11/21/2021
INDIND
+244@
BUFBUF
-310
W
41-15
+7+33 (Y)49.5+6.5 (O)52837031166.70.0
Dallas CowboysDallas Cowboys11/14/2021
DALDAL
-372vs
ATLATL
+286
W
43-3
-7.5+32.5 (Y)55-9 (U)62243121442.9100.0
Dallas CowboysDallas Cowboys12/26/2021
DALDAL
-486vs
WASWAS
+366
W
56-14
-10+32 (Y)46+24 (O)82849725766.7100.0
Buffalo BillsBuffalo Bills9/19/2021
BUFBUF
-188@
MIAMIA
+159
W
35-0
-3.5+31.5 (Y)48-13 (U)52131421653.8100.0
Detroit LionsDetroit Lions12/19/2021
DETDET
+497vs
ARIARI
-710
W
30-12
+13+31 (Y)48-6 (U)32233839846.2100.0
Carolina PanthersCarolina Panthers11/14/2021
CARCAR
+251@
ARIARI
-317
W
34-10
+7+31 (Y)41.5+2.5 (O)32434116946.7
Cincinnati BengalsCincinnati Bengals10/24/2021
CINCIN
+224@
BALBAL
-279
W
41-17
+6.5+30.5 (Y)46+12 (O)51952039330.850.0
Kansas City ChiefsKansas City Chiefs12/12/2021
KCKC
-449vs
LVLV
+343
W
48-9
-9.5+29.5 (Y)48+9 (O)62137229069.2
Philadelphia EaglesPhiladelphia Eagles9/12/2021
PHIPHI
+147@
ATLATL
-175
W
32-6
+3.5+29.5 (Y)48.5-10.5 (U)42443426046.20.0
Jacksonville JaguarsJacksonville Jaguars1/9/2022
JAXJAX
+636vs
INDIND
-995
W
26-11
+14+29 (Y)43-6 (U)21931823346.7100.0
Tennessee TitansTennessee Titans1/2/2022
TENTEN
-165vs
MIAMIA
+139
W
34-3
-3+28 (Y)41-4 (U)41730825646.7100.0
Tennessee TitansTennessee Titans10/24/2021
TENTEN
+166vs
KCKC
-200
W
27-3
+4+28 (Y)59-29 (U)32436933466.7
Arizona CardinalsArizona Cardinals9/12/2021
ARIARI
+131@
TENTEN
-154
W
38-13
+3+28 (Y)51.5-0.5 (U)52241624853.8
Cincinnati BengalsCincinnati Bengals11/28/2021
CINCIN
-185vs
PITPIT
+156
W
41-10
-3.5+27.5 (Y)43.5+7.5 (O)52537030145.5100.0
Cleveland BrownsCleveland Browns11/7/2021
CLECLE
+108@
CINCIN
-129
W
41-16
+2+27 (Y)47.5+9.5 (O)51436134833.3
Arizona CardinalsArizona Cardinals10/17/2021
ARIARI
+129@
CLECLE
-152
W
37-14
+3+26 (Y)48+3 (O)42435229053.3100.0
Buffalo BillsBuffalo Bills1/15/2022
BUFBUF
-216vs
NENE
+175
W
47-17
-4.5+25.5 (Y)43+21 (O)72948230585.7
Houston TexansHouston Texans12/26/2021
HOUHOU
+470vs
LACLAC
-670
W
41-29
+13+25 (Y)45.5+24.5 (O)52643741769.2
New York GiantsNew York Giants10/24/2021
NYGNYG
+129vs
CARCAR
-152
W
25-3
+3+25 (Y)43-15 (U)22130217343.80.0
Baltimore RavensBaltimore Ravens10/17/2021
BALBAL
-159vs
LACLAC
+135
W
34-6
-3+25 (Y)51-11 (U)42732720854.5
Miami DolphinsMiami Dolphins11/28/2021
MIAMIA
+100vs
CARCAR
-120
W
33-10
+1.5+24.5 (Y)41+2 (O)42231519842.9100.0
San Francisco 49ersSan Francisco 49ers11/15/2021
SFSF
+154vs
LARLAR
-184
W
31-10
+3.5+24.5 (Y)50-9 (U)42033527857.150.0
Kansas City ChiefsKansas City Chiefs11/14/2021
KCKC
-149@
LVLV
+127
W
41-14
-2.5+24.5 (Y)53.5+1.5 (O)52951629960.0100.0
Denver BroncosDenver Broncos11/7/2021
DENDEN
+361@
DALDAL
-486
W
30-16
+10+24 (Y)50-4 (U)32340729053.3
New England PatriotsNew England Patriots1/2/2022
NENE
-1308vs
JAXJAX
+775
W
50-10
-17+23 (Y)41.5+18.5 (O)73247125380.0
Tampa Bay BuccaneersTampa Bay Buccaneers10/24/2021
TBTB
-689vs
CHICHI
+492
W
38-3
-12+23 (Y)47-6 (U)52840831133.350.0
Los Angeles ChargersLos Angeles Chargers12/5/2021
LACLAC
+123@
CINCIN
-145
W
41-22
+3+22 (Y)50+13 (O)51836335630.8100.0
Carolina PanthersCarolina Panthers9/19/2021
CARCAR
+132vs
NONO
-155
W
26-7
+3+22 (Y)45-12 (U)32838312853.3