Isaiah McKenzie had 77 catches for 775 yards and scored 11 touchdowns in 23 games for the Bills without Cole Beasley in his career.
| NAME | DATE | TM | OPP | REC | TRG | REC YDS | AVG | REC TD | RUSH YDS | ATT | YPC | RUSH TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | I. McKenzie | 11/11/2018 | @ | 1 | 1 | 14 | 14.0 | 0 | 32 | 3 | 10.7 | 0 | ||
| 2 | | I. McKenzie | 11/25/2018 | vs | 2 | 3 | 11 | 5.5 | 0 | 8 | 2 | 4.0 | 1 | ||
| 3 | | I. McKenzie | 12/2/2018 | @ | 4 | 4 | 46 | 11.5 | 0 | 0 | 0 | 0 | |||
| 4 | | I. McKenzie | 12/9/2018 | vs | 4 | 7 | 47 | 11.8 | 0 | 22 | 4 | 5.5 | 1 | ||
| 5 | | I. McKenzie | 12/16/2018 | vs | 6 | 7 | 53 | 8.8 | 0 | 4 | 1 | 4.0 | 0 | ||
| 6 | | I. McKenzie | 12/23/2018 | @ | 1 | 8 | 8 | 8.0 | 0 | 0 | 0 | 0 | |||
| 7 | | I. McKenzie | 12/30/2018 | vs | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||
| 8 | | I. McKenzie | 12/29/2019 | vs | 2 | 5 | 7 | 3.5 | 0 | 30 | 2 | 15.0 | 0 | ||
| 9 | | I. McKenzie | 1/3/2021 | vs | 6 | 9 | 65 | 10.8 | 2 | 0 | 2 | 0.0 | 0 | ||
| 10 | | I. McKenzie | 12/26/2021 | @ | 11 | 12 | 125 | 11.4 | 1 | -1 | 1 | -1.0 | 0 | ||
| 11 | | I. McKenzie | 9/8/2022 | @ | 2 | 3 | 19 | 9.5 | 1 | 0 | 0 | 0 | |||
| 12 | | I. McKenzie | 9/19/2022 | vs | 2 | 3 | 37 | 18.5 | 0 | 0 | 0 | 0 | |||
| 13 | | I. McKenzie | 9/25/2022 | @ | 7 | 9 | 76 | 10.9 | 1 | 6 | 1 | 6.0 | 0 | ||
| 14 | | I. McKenzie | 10/2/2022 | @ | 4 | 6 | 21 | 5.3 | 1 | 0 | 0 | 0 | |||
| 15 | | I. McKenzie | 10/16/2022 | @ | 2 | 5 | 9 | 4.5 | 0 | 0 | 0 | 0 | |||
| 16 | | I. McKenzie | 10/30/2022 | vs | 1 | 1 | 8 | 8.0 | 0 | 2 | 2 | 1.0 | 1 | ||
| 17 | | I. McKenzie | 11/6/2022 | @ | 2 | 3 | 12 | 6.0 | 0 | 9 | 1 | 9.0 | 0 | ||
| 18 | | I. McKenzie | 11/13/2022 | vs | 4 | 4 | 37 | 9.3 | 0 | 18 | 1 | 18.0 | 0 | ||
| 19 | | I. McKenzie | 11/20/2022 | vs | 0 | 1 | 0 | 0 | 0 | 0 | 0 | ||||
| 20 | | I. McKenzie | 11/24/2022 | @ | 6 | 10 | 96 | 16.0 | 1 | 7 | 2 | 3.5 | 0 | ||
| 21 | | I. McKenzie | 12/1/2022 | @ | 5 | 5 | 44 | 8.8 | 0 | 0 | 0 | 0 | |||
| 22 | | I. McKenzie | 12/11/2022 | vs | 3 | 5 | 21 | 7.0 | 0 | 7 | 1 | 7.0 | 0 | ||
| 23 | | I. McKenzie | 1/8/2023 | vs | 2 | 3 | 19 | 9.5 | 0 | 0 | 0 | 0 | |||
| Average | 3.3 | 5.0 | 33.7 | 10.1 | 0.3 | 6.3 | 1.0 | 6.3 | 0.1 | ||||||
| Total | 77 | 114 | 775 | 10.1 | 7 | 144 | 23 | 6.3 | 3 |
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| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |