The Detroit Lions have a 3-4 record in the regular-season and playoffs versus the Bills at home all-time.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Lions | 11/25/1976 | 1-0 | vs | W 27-14 | 1.000 | 3 | 17 | 304 | 322 | ||||
| 2 | | Lions | 10/28/1979 | 0-1 | vs | L 17-20 | .000 | 2 | 20 | 377 | 424 | ||||
| 3 | | Lions | 11/24/1994 | 1-0 | vs | W 35-21 | 1.000 | 5 | 20 | 388 | 367 | 42.9 | |||
| 4 | | Lions | 10/15/2006 | 1-0 | vs | W 20-17 | 1.000 | 2 | 21 | 397 | 242 | 25.0 | 0.0 | ||
| 5 | | Lions | 10/5/2014 | 0-1 | vs | L 14-17 | .000 | 2 | 13 | 273 | 343 | 9.1 | |||
| 6 | | Lions | 11/24/2022 | 0-1 | vs | L 25-28 | .000 | 3 | 22 | 326 | 401 | 40.0 | 100.0 | ||
| 7 | | Lions | 12/15/2024 | 0-1 | vs | L 42-48 | .000 | 6 | 30 | 521 | 559 | 46.2 | 100.0 | ||
| Average | .429 | 3.3 | 20.4 | 369.4 | 379.7 | 28.6 | |||||||||
| Total | 3-4 | .429 | 23 | 143 | 2,586 | 2,658 | 85.7 |
More Lions Stats
Team Leaders 
PASS
4,564
Goff
RUSH
1,223
Gibbs
REC
1,401
St. Brown
Team Rankings
PPG
28.3
4th
OPP PPG
24.3
22nd
RUSH YDS/G
120.1
14th
PASS YDS/G
268.6
3rd
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
