Patrick Mahomes has a record of 3-3 in the regular-season and playoffs versus the Bills at home in his career.
| NAME | DATE | REC | TM | OPP | W% | CMP | ATT | PCT | YDS | AVG | TD | INT | RTG | TD% | INT% | SCK | SCKY | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | P. Mahomes | 1/24/2021 | 1-0 | vs | 1.000 | 29 | 38 | 76.3 | 325 | 8.6 | 3 | 0 | 127.6 | 7.9 | 0.0 | 1 | 0 | ||
| 2 | | P. Mahomes | 10/10/2021 | 0-1 | vs | .000 | 33 | 54 | 61.1 | 272 | 5.0 | 2 | 2 | 70.9 | 3.7 | 3.7 | 2 | 0 | ||
| 3 | | P. Mahomes | 1/23/2022 | 1-0 | vs | 1.000 | 33 | 44 | 75.0 | 378 | 8.6 | 3 | 0 | 123.1 | 6.8 | 0.0 | 2 | 8 | ||
| 4 | | P. Mahomes | 10/16/2022 | 0-1 | vs | .000 | 25 | 40 | 62.5 | 338 | 8.5 | 2 | 2 | 85.2 | 5.0 | 5.0 | 3 | 19 | ||
| 5 | | P. Mahomes | 12/10/2023 | 0-1 | vs | .000 | 25 | 43 | 58.1 | 271 | 6.3 | 1 | 1 | 74.9 | 2.3 | 2.3 | 1 | 7 | ||
| 6 | | P. Mahomes | 1/26/2025 | 1-0 | vs | 1.000 | 18 | 26 | 69.2 | 245 | 9.4 | 1 | 0 | 111.9 | 3.8 | 0.0 | 2 | 12 | ||
| Average | .500 | 27.2 | 40.8 | 66.5 | 304.8 | 7.5 | 2.0 | 0.8 | 96.5 | 4.9 | 2.0 | 1.8 | 7.7 | |||||||
| Total | 3-3 | .500 | 163 | 245 | 66.5 | 1,829 | 7.5 | 12 | 5 | 96.5 | 4.9 | 2.0 | 11 | 46 |
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More Chiefs Stats
Team Leaders 
PASS
3,587
Mahomes
RUSH
611
Hunt
REC
851
Kelce
Team Rankings
PPG
21.3
21st
OPP PPG
19.3
6th
RUSH YDS/G
106.6
25th
PASS YDS/G
232.2
16th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |