Adrian Peterson and O.J. Simpson were tied for the most games with 200+ rushing yards, with 6 games.

most games with 200 rushing yards
Interpreted as:
most regular-season games by a player with 200 or more rushing yards
PetersonSimpsonHenryBarberTomlinsonSandersCampbellAjayiCharlesLewisFaulkDillonDavisBellDickersonBrownBellMartinTurnerGoreParkerJohnsonPortis66554443333333332222222
NAMEGPRUSH YDSATTRUSH AVGRUSH YDS/GRUSH TDREC YDSRECTRGREC AVGREC YDS/GREC TD
Adrian PetersonAdrian Peterson61,3561568.7226.09517137.38.50
O.J. SimpsonO.J. Simpson61,3721668.3228.781226.02.00
Derrick HenryDerrick Henry51,1261318.6225.213594714.811.80
Tiki BarberTiki Barber51,0661367.8213.2719123298.338.20
LaDainian TomlinsonLaDainian Tomlinson48801217.3220.0810926394.227.30
Barry SandersBarry Sanders4888979.2222.086488.016.01
Earl CampbellEarl Campbell48141206.8203.53723.51.80
Jay AjayiJay Ajayi3624857.3208.048342.72.70
Jamaal CharlesJamaal Charles3718809.0239.34628127.820.70
Jamal LewisJamal Lewis3716799.1238.7521367.07.00
Marshall FaulkMarshall Faulk3630877.2210.0516917219.956.31
Corey DillonCorey Dillon3740967.7246.77302015.010.00
Terrell DavisTerrell Davis3630996.4210.034276.014.00
Greg BellGreg Bell3637817.9212.341635.35.31
Eric DickersonEric Dickerson3630788.1210.0438219.012.70
Jim BrownJim Brown3692828.4230.7752317.317.30
Le'Veon BellLe'Veon Bell2440716.2220.04806913.340.00
Doug MartinDoug Martin2486529.3243.0421465.310.50
Michael TurnerMichael Turner2428479.1214.036116.03.00
Frank GoreFrank Gore24194010.5209.5265997.232.50
Willie ParkerWillie Parker2436548.1218.0312236.06.00
Larry JohnsonLarry Johnson2412626.6206.0527339.013.50
Clinton PortisClinton Portis2446469.7223.07544513.527.00
Ricky WilliamsRicky Williams2444587.7222.047491.83.50
Shaun AlexanderShaun Alexander2467756.2233.537127.03.50
StatMuse has game-level data for rushing yards going back to the 1960 season.

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