Randy Starks, Dwight White and Frank Cornish are tied for the most interceptions by a defensive lineman in a game, with 2 interceptions.

most interceptions in a game by a defensive end
Interpreted as:
most defensive interceptions in a regular-season game by a defensive end
1/1/2012Starks10/23/1977White11/11/1973White11/12/1967Cornish12/20/2020Payne12/6/2020Nichols12/6/2020Winovich11/29/2020Lalos11/29/2020Kinlaw11/26/2020Watt11/26/2020Sweat11/23/2020Pierre-Paul11/15/2020Pierre-Paul11/15/2020Nassib11/8/2020Onyemata11/1/2020Wilkins10/25/2020Hughes10/18/2020Williams9/14/2020Heyward9/13/2020Ingram12/15/2019Lowry12/15/2019Ingram12/8/2019Hurst22221111111111111111111
Results may be incomplete. StatMuse has complete game-level data for interceptions going back to the 1960 season.

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