From 2010 through 2020, LeSean McCoy collected the most PPR fantasy points for the Bills by a running back in a season, with 298.3 points in 2016.
| NAME | FPTS (PPR) | SEASON | TM | GP | FPTS | FPTS (Half PPR) | RUSH YDS | ATT | YPC | RUSH YDS/G | RUSH TD | REC YDS | REC | TRG | AVG | REC YDS/G | REC TD | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | L. McCoy | 298.3 | 2016 | 15 | 248.3 | 273.3 | 1,267 | 234 | 5.4 | 84.5 | 13 | 356 | 50 | 57 | 7.1 | 23.7 | 1 | |
| 2 | | L. McCoy | 263.6 | 2017 | 16 | 204.6 | 234.1 | 1,138 | 287 | 4.0 | 71.1 | 6 | 448 | 59 | 77 | 7.6 | 28.0 | 2 | |
| 3 |  | C.J. Spiller | 255.3 | 2012 | 16 | 212.3 | 233.8 | 1,244 | 207 | 6.0 | 77.8 | 6 | 459 | 43 | 57 | 10.7 | 28.7 | 2 | |
| 4 | | F. Jackson | 234.7 | 2013 | 16 | 187.7 | 211.2 | 890 | 206 | 4.3 | 55.6 | 9 | 387 | 47 | 66 | 8.2 | 24.2 | 1 | |
| 5 | | F. Jackson | 208.6 | 2011 | 10 | 169.6 | 189.1 | 934 | 170 | 5.5 | 93.4 | 6 | 442 | 39 | 50 | 11.3 | 44.2 | 0 | |
| 6 | | F. Jackson | 188.6 | 2014 | 14 | 122.6 | 155.6 | 525 | 141 | 3.7 | 37.5 | 2 | 501 | 66 | 90 | 7.6 | 35.8 | 1 | |
| 7 | | F. Jackson | 183.2 | 2010 | 16 | 152.2 | 167.7 | 927 | 222 | 4.2 | 57.9 | 5 | 215 | 31 | 54 | 6.9 | 13.4 | 2 | |
| 8 | | L. McCoy | 178.7 | 2015 | 12 | 146.7 | 162.7 | 895 | 203 | 4.4 | 74.6 | 3 | 292 | 32 | 50 | 9.1 | 24.3 | 2 | |
| 9 | | C.J. Spiller | 158 | 2011 | 16 | 119 | 138.5 | 561 | 107 | 5.2 | 35.1 | 4 | 269 | 39 | 53 | 6.9 | 16.8 | 2 | |
| 10 | | C.J. Spiller | 154.8 | 2013 | 15 | 121.8 | 138.3 | 933 | 202 | 4.6 | 62.2 | 2 | 185 | 33 | 40 | 5.6 | 12.3 | 0 | |
| 11 |  | D. Singletary | 147.9 | 2019 | 12 | 118.9 | 133.4 | 775 | 151 | 5.1 | 64.6 | 2 | 194 | 29 | 41 | 6.7 | 16.2 | 2 | |
| 12 | | D. Singletary | 143.6 | 2020 | 16 | 105.6 | 124.6 | 687 | 156 | 4.4 | 42.9 | 2 | 269 | 38 | 50 | 7.1 | 16.8 | 0 | |
| 13 | | L. McCoy | 127.2 | 2018 | 14 | 93.2 | 110.2 | 514 | 161 | 3.2 | 36.7 | 3 | 238 | 34 | 46 | 7.0 | 17.0 | 0 | |
| 14 | | M. Gillislee | 125.7 | 2016 | 15 | 116.7 | 121.2 | 577 | 101 | 5.7 | 38.5 | 8 | 50 | 9 | 11 | 5.6 | 3.3 | 1 | |
| 15 | | K. Williams | 124.3 | 2015 | 11 | 113.3 | 118.8 | 517 | 93 | 5.6 | 47.0 | 7 | 96 | 11 | 14 | 8.7 | 8.7 | 2 | |
| 16 | | F. Jackson | 115.4 | 2012 | 10 | 81.4 | 98.4 | 437 | 115 | 3.8 | 43.7 | 3 | 217 | 34 | 42 | 6.4 | 21.7 | 1 | |
| 17 |  | Z. Moss | 101.6 | 2020 | 13 | 87.6 | 94.6 | 481 | 112 | 4.3 | 37.0 | 4 | 95 | 14 | 18 | 6.8 | 7.3 | 1 | |
| 18 |  | F. Gore | 94.9 | 2019 | 16 | 81.9 | 88.4 | 599 | 166 | 3.6 | 37.4 | 2 | 100 | 13 | 16 | 7.7 | 6.3 | 0 | |
| 19 | | C. Ivory | 78 | 2018 | 13 | 65 | 71.5 | 385 | 115 | 3.3 | 29.6 | 1 | 205 | 13 | 21 | 15.8 | 15.8 | 0 | |
| 20 | | C.J. Spiller | 74 | 2010 | 14 | 50 | 62 | 283 | 74 | 3.8 | 20.2 | 0 | 157 | 24 | 30 | 6.5 | 11.2 | 1 | |
| 21 | | C.J. Spiller | 71.5 | 2014 | 9 | 52.5 | 62 | 300 | 78 | 3.8 | 33.3 | 0 | 125 | 19 | 22 | 6.6 | 13.9 | 1 | |
| 22 | | A. Dixon | 68.1 | 2014 | 16 | 60.1 | 64.1 | 432 | 105 | 4.1 | 27.0 | 2 | 49 | 8 | 9 | 6.1 | 3.1 | 0 | |
| 23 | | M. Gillislee | 51.6 | 2015 | 5 | 45.6 | 48.6 | 267 | 47 | 5.7 | 53.4 | 3 | 29 | 6 | 7 | 4.8 | 5.8 | 0 | |
| 24 | | M. Tolbert | 50.5 | 2017 | 12 | 36.5 | 43.5 | 247 | 66 | 3.7 | 20.6 | 1 | 78 | 14 | 17 | 5.6 | 6.5 | 0 | |
| 25 | | B. Brown | 44.2 | 2014 | 7 | 28.2 | 36.2 | 126 | 36 | 3.5 | 18.0 | 0 | 176 | 16 | 25 | 11.0 | 25.1 | 0 | |
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| NFC East | W | L | T | PCT |
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0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
| NFC North | W | L | T | PCT |
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
| NFC South | W | L | T | PCT |
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 | ||
| NFC West | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 0 | 0 |
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