Christian McCaffrey has the most career fantasy points per game played by a running back, with 22.47.

most ppr points per game in a career for an rb
McCaffreyWilliamsKamaraTomlinsonFaulkTaylorFosterWilliamsCookElliottHolmesHarrisBarkleyBellGurleyJamesMartinPortisRiceForteBarberSmith22.4721.321.0420.3719.9319.5619.1818.8318.8218.6917.817.6917.6417.5617.5517.0816.8816.8816.7216.6516.5316.49
NAMEGPFPTS (PPR)/GPFPTS (PPR)FPTSFPTS (HALF PPR)RUSH YDSATTYPCRUSH YDS/GRUSH TDREC YDSRECTRGAVGREC YDS/GREC TD
Christian McCaffreyChristian McCaffrey5822.471,303.2946.21,124.73,5877814.661.8303,0153574388.452.017
Antonio WilliamsAntonio Williams121.321.320.320.863125.363.02201120.020.00
Alvin KamaraAlvin Kamara7321.041,535.61,162.61,349.14,2389124.658.1473,2633734768.744.720
LaDainian TomlinsonLaDainian Tomlinson17020.373,463.32,839.33,151.313,6843,1744.380.51454,7726248687.628.117
Marshall FaulkMarshall Faulk17619.933,508.42,741.43,124.912,2792,8364.369.81006,8757676069.039.136
Jonathan TaylorJonathan Taylor3219.56625.9549.9587.92,9805645.393.12965976908.720.63
Arian FosterArian Foster8019.181,534.51,279.51,4076,5271,4764.481.6542,3462553559.229.314
Domanick WilliamsDomanick Williams4018.83753.1599.1676.13,1957704.179.9231,2761542008.331.95
Dalvin CookDalvin Cook5618.821,053.9871.9962.94,8201,0184.786.1391,4991822318.226.83
Ezekiel ElliottEzekiel Elliott8818.691,645.21,357.21,501.27,3861,6504.583.9562,2442883807.825.512
Priest HolmesPriest Holmes11317.82,011.41,672.41,841.98,1721,7804.672.3862,9623393768.726.28
Najee HarrisNajee Harris1717.69300.7226.7263.71,2003073.970.6746774946.327.53
Saquon BarkleySaquon Barkley4517.64793.9603.9698.92,9376594.565.3191,4821902607.832.98
Le'Veon BellLe'Veon Bell9617.561,685.31,286.31,485.86,5541,5954.168.3423,2893995028.234.39
Todd GurleyTodd Gurley8817.551,544.61,301.61,423.16,0821,4604.269.1672,2542433369.325.612
Edgerrin JamesEdgerrin James14817.082,5282,0952,311.512,2463,0284.082.7803,3644335847.822.711
Curtis MartinCurtis Martin16816.882,836.42,352.42,594.414,1013,5184.083.9903,3294844096.919.810
Clinton PortisClinton Portis11316.881,9071,6601,783.59,9232,2304.487.8752,0182473388.217.95
Ray RiceRay Rice9216.721,538.41,169.41,353.96,1801,4304.367.2373,0343694878.233.06
Matt ForteMatt Forte14616.652,430.81,876.82,153.89,7962,3564.267.1544,6725547248.432.021
Tiki BarberTiki Barber15416.532,545.21,959.22,252.210,4492,2174.767.9555,1835867078.833.712
Emmitt SmithEmmitt Smith22616.493,727.73,212.73,470.218,3554,4094.281.21643,2245151306.314.311
Wes HillsWes Hills116.216.214.215.221102.121.021220.51.00
Kareem HuntKareem Hunt5916.19955.3779.3867.33,5577724.660.3281,5961762209.127.116
Shaun AlexanderShaun Alexander12315.971,964.31,749.31,856.89,4532,1874.376.91001,5202153167.112.412