O.J. Simpson has the most rushing yards for the Bills in a regular-season or postseason game, with 273 yards against the Lions on November 25, 1976.
Showing
| NAME | RUSH YDS | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | O.J. Simpson | 273 | 11/25/1976 | @ | 29 | 9.4 | 2 | 0 | 0 | 0 | ||||
| 2 | | O.J. Simpson | 250 | 9/16/1973 | @ | 29 | 8.6 | 2 | 0 | 0 | 0 | ||||
| 3 |  | C. Gilchrist | 243 | 12/8/1963 | vs | 36 | 6.8 | 5 | 0 | 0 | 0 | ||||
| 4 | | O.J. Simpson | 227 | 9/28/1975 | @ | 28 | 8.1 | 1 | 0 | 0 | 0 | ||||
| 5 | | O.J. Simpson | 219 | 12/9/1973 | vs | 22 | 10.0 | 1 | 0 | 0 | 0 | ||||
| 6 |  | J. Cook III | 216 | 10/26/2025 | @ | 19 | 11.4 | 2 | 0 | 0 | 0 | 0 | |||
| 7 | | T. Thomas | 214 | 9/24/1990 | @ | 18 | 11.9 | 0 | 5 | 3 | 1.7 | 0 | |||
| 8 | | F. Jackson | 212 | 1/3/2010 | vs | 33 | 6.4 | 0 | 15 | 2 | 2 | 7.5 | 1 | ||
| 9 | | T. Miller | 208 | 11/26/1978 | vs | 21 | 9.9 | 2 | 7 | 2 | 3.5 | 0 | |||
| 10 | | G. Bell | 206 | 11/18/1984 | vs | 27 | 7.6 | 1 | 12 | 2 | 6.0 | 1 | |||
| 11 | | O.J. Simpson | 203 | 12/5/1976 | @ | 24 | 8.5 | 1 | 12 | 2 | 6.0 | 0 | |||
| 12 | | O.J. Simpson | 200 | 12/16/1973 | @ | 34 | 5.9 | 1 | 0 | 0 | 0 | ||||
| 13 | | O.J. Simpson | 197 | 11/17/1975 | @ | 17 | 11.6 | 2 | 21 | 2 | 10.5 | 0 | |||
| 14 | | O.J. Simpson | 189 | 10/29/1972 | vs | 22 | 8.6 | 1 | 7 | 3 | 2.3 | 0 | |||
| 15 | | T. Thomas | 186 | 1/23/1994 | vs | 33 | 5.6 | 3 | 22 | 2 | 11.0 | 0 | |||
| 16 | | J. Cribbs | 185 | 12/4/1983 | @ | 36 | 5.1 | 0 | 0 | 0 | 0 | ||||
| 17 | | O.J. Simpson | 185 | 12/14/1975 | @ | 21 | 8.8 | 1 | 28 | 2 | 14.0 | 0 | |||
| 18 | | K. Davis | 181 | 11/22/1992 | vs | 20 | 9.1 | 2 | 4 | 1 | 4.0 | 0 | |||
| 19 | | J. Cook III | 179 | 12/17/2023 | vs | 25 | 7.2 | 1 | 42 | 2 | 3 | 21.0 | 1 | ||
| 20 | | O.J. Simpson | 173 | 9/21/1975 | vs | 32 | 5.4 | 2 | 5 | 1 | 5.0 | 0 | |||
| 21 | | O.J. Simpson | 171 | 12/12/1976 | @ | 28 | 6.1 | 1 | 18 | 1 | 18.0 | 0 | |||
| 22 | | O.J. Simpson | 171 | 10/7/1973 | vs | 27 | 6.3 | 1 | 33 | 3 | 11.0 | 0 | |||
| 23 | | C.J. Spiller | 169 | 9/9/2012 | @ | 14 | 12.1 | 1 | 25 | 2 | 3 | 12.5 | 0 | ||
| 24 | | T. Henry | 169 | 12/7/2003 | vs | 32 | 5.3 | 1 | 6 | 1 | 1 | 6.0 | 0 | ||
| 25 | | T. Henry | 167 | 10/19/2003 | vs | 31 | 5.4 | 2 | 13 | 1 | 2 | 13.0 | 0 | ||
BUF
DET
NE
NYJ
PIT
CAR
IND
NYG
DAL
MIA
CIN
KC
ATL
BAL
PHI
NYJ
WASMore NFL News
Eagles running back Saquon Barkley said he'd love to stay with Eagles
Jayden Daniels throws TD pass and Commanders shut out Eagles over final 3 quarters in 27-10 win
Chargers' reeling offense offers up more of the same coming out of bye week
On fourth-and-goal, Roach drops Mahomes and flips the AFC West race as Broncos beat Chiefs 28-24
Titans allow big game by Burrow but still point to positive signs on defense after trading Simmons
Jerry Jones calls it 'an indictment of the whole show' after Cowboys collapse against Cards
More Bills Stats
Team Leaders 
PASS
1,793
Allen
RUSH
707
Cook
REC
401
Kincaid
Team Rankings
PPG
33.3
1st
OPP PPG
25.9
24th
RUSH YDS/G
148.4
3rd
PASS YDS/G
256.1
9th
MIN
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
4 | 2 | 1 | .643 | |
3 | 5 | 0 | .375 | |
2 | 4 | 1 | .357 | |
2 | 6 | 0 | .250 | |
| NFC North | W | L | T | PCT |
6 | 1 | 0 | .857 | |
5 | 2 | 0 | .714 | |
5 | 2 | 0 | .714 | |
5 | 3 | 0 | .625 | |
| NFC South | W | L | T | PCT |
3 | 4 | 0 | .429 | |
3 | 5 | 0 | .375 | |
3 | 5 | 0 | .375 | |
2 | 5 | 0 | .286 | |
| NFC West | W | L | T | PCT |
6 | 1 | 0 | .857 | |
4 | 3 | 0 | .571 | |
4 | 4 | 0 | .500 | |
3 | 5 | 0 | .375 |
Commanders
Bears
Packers
Buccaneers
Saints
49ers
Seahawks
Rams
Cardinals| AFC East | W | L | T | PCT |
|---|---|---|---|---|
6 | 1 | 0 | .857 | |
5 | 3 | 0 | .625 | |
2 | 6 | 0 | .250 | |
1 | 6 | 0 | .143 | |
| AFC North | W | L | T | PCT |
6 | 2 | 0 | .750 | |
5 | 2 | 0 | .714 | |
5 | 3 | 0 | .625 | |
4 | 4 | 0 | .500 | |
| AFC South | W | L | T | PCT |
5 | 2 | 0 | .714 | |
2 | 5 | 0 | .286 | |
2 | 6 | 0 | .250 | |
1 | 7 | 0 | .125 | |
| AFC West | W | L | T | PCT |
6 | 2 | 0 | .750 | |
5 | 2 | 0 | .714 | |
4 | 4 | 0 | .500 | |
0 | 7 | 0 | .000 |
Browns
Ravens
Jaguars
Texans
Titans
Broncos
Raiders
Chargers