O.J. Simpson has rushed for the most yards for the Bills in a game, with 273 yards against the Lions on November 25, 1976.
Interpreted as:
most rushing yards in a regular-season game by a bills player| NAME | RUSH YDS | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | O.J. Simpson | 273 | 11/25/1976 | @ | 29 | 9.4 | 2 | 0 | 0 | 0 | ||||
| 2 | | O.J. Simpson | 250 | 9/16/1973 | @ | 29 | 8.6 | 2 | 0 | 0 | 0 | ||||
| 3 |  | C. Gilchrist | 243 | 12/8/1963 | vs | 36 | 6.8 | 5 | 0 | 0 | 0 | ||||
| 4 | | O.J. Simpson | 227 | 9/28/1975 | @ | 28 | 8.1 | 1 | 0 | 0 | 0 | ||||
| 5 | | O.J. Simpson | 219 | 12/9/1973 | vs | 22 | 10.0 | 1 | 0 | 0 | 0 | ||||
| 6 |  | J. Cook III | 216 | 10/26/2025 | @ | 19 | 11.4 | 2 | 0 | 0 | 0 | 0 | |||
| 7 | | T. Thomas | 214 | 9/24/1990 | @ | 18 | 11.9 | 0 | 5 | 3 | 1.7 | 0 | |||
| 8 | | F. Jackson | 212 | 1/3/2010 | vs | 33 | 6.4 | 0 | 15 | 2 | 2 | 7.5 | 1 | ||
| 9 | | T. Miller | 208 | 11/26/1978 | vs | 21 | 9.9 | 2 | 7 | 2 | 3.5 | 0 | |||
| 10 | | G. Bell | 206 | 11/18/1984 | vs | 27 | 7.6 | 1 | 12 | 2 | 6.0 | 1 | |||
| 11 | | O.J. Simpson | 203 | 12/5/1976 | @ | 24 | 8.5 | 1 | 12 | 2 | 6.0 | 0 | |||
| 12 | | O.J. Simpson | 200 | 12/16/1973 | @ | 34 | 5.9 | 1 | 0 | 0 | 0 | ||||
| 13 | | O.J. Simpson | 197 | 11/17/1975 | @ | 17 | 11.6 | 2 | 21 | 2 | 10.5 | 0 | |||
| 14 | | O.J. Simpson | 189 | 10/29/1972 | vs | 22 | 8.6 | 1 | 7 | 3 | 2.3 | 0 | |||
| 15 | | J. Cribbs | 185 | 12/4/1983 | @ | 36 | 5.1 | 0 | 0 | 0 | 0 | ||||
| 16 | | O.J. Simpson | 185 | 12/14/1975 | @ | 21 | 8.8 | 1 | 28 | 2 | 14.0 | 0 | |||
| 17 | | K. Davis | 181 | 11/22/1992 | vs | 20 | 9.1 | 2 | 4 | 1 | 4.0 | 0 | |||
| 18 | | J. Cook III | 179 | 12/17/2023 | vs | 25 | 7.2 | 1 | 42 | 2 | 3 | 21.0 | 1 | ||
| 19 | | O.J. Simpson | 173 | 9/21/1975 | vs | 32 | 5.4 | 2 | 5 | 1 | 5.0 | 0 | |||
| 20 | | O.J. Simpson | 171 | 12/12/1976 | @ | 28 | 6.1 | 1 | 18 | 1 | 18.0 | 0 | |||
| 21 | | O.J. Simpson | 171 | 10/7/1973 | vs | 27 | 6.3 | 1 | 33 | 3 | 11.0 | 0 | |||
| 22 | | C.J. Spiller | 169 | 9/9/2012 | @ | 14 | 12.1 | 1 | 25 | 2 | 3 | 12.5 | 0 | ||
| 23 | | T. Henry | 169 | 12/7/2003 | vs | 32 | 5.3 | 1 | 6 | 1 | 1 | 6.0 | 0 | ||
| 24 | | T. Henry | 167 | 10/19/2003 | vs | 31 | 5.4 | 2 | 13 | 1 | 2 | 13.0 | 0 | ||
| 25 | | J. Cribbs | 166 | 9/25/1983 | vs | 22 | 7.5 | 1 | 0 | 0 | 0 | ||||
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HOUResults may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.
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Team Leaders 
PASS
3,668
Allen
RUSH
1,621
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REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
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NFL 2025 Rankings
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NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |