James Cook III has the most rushing yards in a game against the Panthers, with 216 yards on October 26, 2025.
| NAME | RUSH YDS | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | J. Cook III | 216 | 10/26/2025 | @ | 19 | 11.4 | 2 | 0 | 0 | 0 | 0 | |||
| 2 |  | D. Ward | 215 | 12/21/2008 | vs | 15 | 14.3 | 0 | -5 | 1 | 2 | -5.0 | 0 | ||
| 3 |  | M. Forte | 205 | 10/2/2011 | vs | 25 | 8.2 | 1 | 23 | 4 | 5 | 5.8 | 0 | ||
| 4 |  | M. Faulk | 202 | 12/23/2001 | @ | 30 | 6.7 | 2 | 50 | 3 | 3 | 16.7 | 0 | ||
| 5 | | S. Alexander | 195 | 10/31/2004 | vs | 32 | 6.1 | 1 | 13 | 3 | 4 | 4.3 | 1 | ||
| 6 | | J. Jones | 194 | 12/24/2005 | @ | 34 | 5.7 | 2 | 17 | 2 | 2 | 8.5 | 0 | ||
| 7 | | R. Droughns | 193 | 10/10/2004 | vs | 30 | 6.4 | 0 | 18 | 4 | 5 | 4.5 | 1 | ||
| 8 |  | R. Jones | 192 | 11/15/2020 | @ | 23 | 8.3 | 1 | 6 | 1 | 2 | 6.0 | 0 | ||
| 9 | | M. Faulk | 183 | 11/11/2001 | vs | 15 | 12.2 | 2 | 14 | 4 | 5 | 3.5 | 0 | ||
| 10 | | B. Brown | 178 | 11/26/2012 | vs | 19 | 9.4 | 2 | 11 | 4 | 5 | 2.8 | 0 | ||
| 11 |  | B. Robinson | 170 | 1/5/2025 | vs | 28 | 6.1 | 2 | 3 | 2 | 5 | 1.5 | 0 | ||
| 12 | | M. Forte | 166 | 10/10/2010 | @ | 22 | 7.5 | 2 | 22 | 2 | 2 | 11.0 | 0 | ||
| 13 |  | C. Martin | 159 | 10/28/2001 | @ | 27 | 5.9 | 0 | 39 | 7 | 7 | 5.6 | 0 | ||
| 14 |  | A. Kamara | 155 | 11/3/2024 | @ | 29 | 5.3 | 0 | 60 | 6 | 9 | 10.0 | 0 | ||
| 15 |  | J. Mixon | 153 | 11/6/2022 | vs | 22 | 7.0 | 4 | 58 | 4 | 5 | 14.5 | 1 | ||
| 16 |  | B. Irving | 152 | 12/1/2024 | @ | 25 | 6.1 | 1 | 33 | 3 | 3 | 11.0 | 0 | ||
| 17 |  | R. Dowdle | 149 | 12/15/2024 | @ | 25 | 6.0 | 0 | 0 | 0 | 0 | 0 | |||
| 18 |  | L. Bell | 147 | 9/21/2014 | @ | 21 | 7.0 | 0 | 10 | 2 | 4 | 5.0 | 0 | ||
| 19 | | R. Williams | 147 | 10/14/2001 | @ | 31 | 4.7 | 1 | 31 | 4 | 7 | 7.8 | 0 | ||
| 20 |  | A. Jones Sr. | 145 | 12/19/2020 | vs | 20 | 7.3 | 1 | 13 | 3 | 4 | 4.3 | 0 | ||
| 21 | | T. Canidate | 145 | 11/11/2001 | vs | 16 | 9.1 | 1 | 1 | 1 | 2 | 1.0 | 0 | ||
| 22 | | R. Williams | 144 | 10/15/2000 | vs | 38 | 3.8 | 2 | 35 | 3 | 4 | 11.7 | 0 | ||
| 23 |  | T. Etienne Jr. | 143 | 9/7/2025 | vs | 16 | 8.9 | 0 | 13 | 3 | 3 | 4.3 | 0 | ||
| 24 |  | E. Elliott | 143 | 10/3/2021 | vs | 20 | 7.2 | 1 | 0 | 0 | 1 | 0 | |||
| 25 |  | N. Chubb | 141 | 9/11/2022 | @ | 22 | 6.4 | 0 | 2 | 1 | 1 | 2.0 | 0 | ||
BUF
CAR
NYG
CHI
STL
SEA
DAL
DEN
TB
PHI
ATL
NYJ
NO
CIN
PIT
GB
JAX
CLEResults may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.
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More Bills Stats
Team Leaders 
PASS
1,039
Allen
RUSH
421
Cook
REC
270
Kincaid
Team Rankings
PPG
31.8
1st
OPP PPG
26.8
25th
RUSH YDS/G
139.0
5th
PASS YDS/G
259.8
9th
Patriots
Jets
Dolphins
LAR
LV
BAL
MIN
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
2 | 2 | 0 | .500 | |
1 | 3 | 0 | .250 | |
| NFC North | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
2 | 2 | 0 | .500 | |
| NFC South | W | L | T | PCT |
2 | 2 | 0 | .500 | |
2 | 2 | 0 | .500 | |
1 | 3 | 0 | .250 | |
0 | 4 | 0 | .000 | |
| NFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
1 | 3 | 0 | .250 |
Commanders
Bears
Lions
49ers
Cardinals| AFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
1 | 3 | 0 | .250 | |
0 | 4 | 0 | .000 | |
| AFC North | W | L | T | PCT |
3 | 1 | 0 | .750 | |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
2 | 2 | 0 | .500 | |
| AFC South | W | L | T | PCT |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
0 | 4 | 0 | .000 | |
0 | 4 | 0 | .000 | |
| AFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
0 | 4 | 0 | .000 |
Colts
Titans
Texans
Chiefs
Chargers