most rushing yards in a single game by a buffalo bill

O.J. Simpson has the most rushing yards for the Bills in a game, with 273 yards against the Lions on November 25, 1976.

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Assumption:All-time
Data note: Rushing Yards: player game data may be incomplete before 1960

	NAME	RUSH YDS	DATE	TM		OPP	ATT	YPC	RUSH TD	REC YDS	REC	TRG	AVG	REC TD
1	O.J. Simpson	273	11/25/1976	BUF	@	DET	29	9.4	2	0	0			0
2	O.J. Simpson	250	9/16/1973	BUF	@	NE	29	8.6	2	0	0			0
3	Cookie Gilchrist C. Gilchrist	243	12/8/1963	BUF	vs	NYJ	36	6.8	5	0	0			0
4	O.J. Simpson	227	9/28/1975	BUF	@	PIT	28	8.1	1	0	0			0
5	O.J. Simpson	219	12/9/1973	BUF	vs	NE	22	10.0	1	0	0			0
6	James Cook III J. Cook III	216	10/26/2025	BUF	@	CAR	19	11.4	2	0	0	0		0
7	Thurman Thomas T. Thomas	214	9/24/1990	BUF	@	NYJ	18	11.9	0	5	3		1.7	0
8	Fred Jackson F. Jackson	212	1/3/2010	BUF	vs	IND	33	6.4	0	15	2	2	7.5	1
9	Terry Miller T. Miller	208	11/26/1978	BUF	vs	NYG	21	9.9	2	7	2		3.5	0
10	Greg Bell G. Bell	206	11/18/1984	BUF	vs	DAL	27	7.6	1	12	2		6.0	1
11	O.J. Simpson	203	12/5/1976	BUF	@	MIA	24	8.5	1	12	2		6.0	0
12	O.J. Simpson	200	12/16/1973	BUF	@	NYJ	34	5.9	1	0	0			0
13	O.J. Simpson	197	11/17/1975	BUF	@	CIN	17	11.6	2	21	2		10.5	0
14	O.J. Simpson	189	10/29/1972	BUF	vs	PIT	22	8.6	1	7	3		2.3	0
15	Joe Cribbs J. Cribbs	185	12/4/1983	BUF	@	KC	36	5.1	0	0	0			0
16	O.J. Simpson	185	12/14/1975	BUF	@	NE	21	8.8	1	28	2		14.0	0
17	Kenneth Davis K. Davis	181	11/22/1992	BUF	vs	ATL	20	9.1	2	4	1		4.0	0
18	James Cook III J. Cook III	179	12/17/2023	BUF	vs	DAL	25	7.2	1	42	2	3	21.0	1
19	O.J. Simpson	173	9/21/1975	BUF	vs	NYJ	32	5.4	2	5	1		5.0	0
20	O.J. Simpson	171	12/12/1976	BUF	@	BAL	28	6.1	1	18	1		18.0	0
21	O.J. Simpson	171	10/7/1973	BUF	vs	PHI	27	6.3	1	33	3		11.0	0
22	C.J. Spiller	169	9/9/2012	BUF	@	NYJ	14	12.1	1	25	2	3	12.5	0
23	Travis Henry T. Henry	169	12/7/2003	BUF	vs	NYJ	32	5.3	1	6	1	1	6.0	0
24	Travis Henry T. Henry	167	10/19/2003	BUF	vs	WAS	31	5.4	2	13	1	2	13.0	0
25	Joe Cribbs J. Cribbs	166	9/25/1983	BUF	vs	HOU	22	7.5	1	0	0			0

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More Bills Stats

Team Leaders

PASS

1,793

Allen

RUSH

707

Cook

REC

401

Kincaid

Team Rankings

PPG

33.3

1st

OPP PPG

25.9

23rd

RUSH YDS/G

148.4

3rd

PASS YDS/G

256.1

9th

2026 Division Standings

TEAM	W	L	PCT
Bills	6	1	.857
Patriots	5	3	.625
Jets	2	6	.250
Dolphins	1	6	.143

Schedule

DATE	MATCHUP			TIME (ET)
Mon 11/9	BUF	@	MIN	8:15 PM
Sun 11/15	BUF	@	NYJ	1:00 PM
Sun 11/22	MIA	@	BUF	1:00 PM
Thu 11/26	KC	@	BUF	8:20 PM
Sun 12/6	BUF	@	NE	4:25 PM

Last Game

Ravens

4 - 4

Final

Bills

6 - 1

Sun 1 Nov 2026

NFL 2026 Leaders

Pass Yards Leaders

2,246

Love

2,146

Stafford

2,124

Cousins

Rush Yards Leaders

780

Robinson

773

Gibbs

770

Walker

Rec Yards Leaders

985

Smith-Njigba

726

Higgins

709

Lamb

Pass TD Leaders

20

Burrow

19

Cousins

18

Lawrence

Rush TD Leaders

10

Swift

9

Allen

8

Gibbs

Rec TD Leaders

9

Smith-Njigba

6

Watson

6

Chase

QB Rating Leaders

111.7

Lawrence

111.6

Burrow

110.1

Purdy

Sack Leaders

7.5

Anderson

7.5

Watt

7.0

Rousseau

NFL 2026 Rankings

PPG Rankings

33.3

29.4

29.0

28.6

28.1

27.6

Opp PPG Rankings

13.3

15.1

18.0

18.7

18.9

19.9

Total Yards Rankings

395.4

393.1

387.3

384.4

383.1

371.4

Rush Yards Rankings

168.6

150.8

148.4

137.8

134.8

134.1

Pass Yards Rankings

302.1

281.1

280.8

280.6

273.1

269.9

Sack Leaders

26.0

25.0

24.0

23.0

22.0

NFL Fantasy 2026

Fantasy RB Rankings

161.8

Gibbs

138.1

Walker

130.3

Henry

Fantasy WR Rankings

156

Smith-Njigba

108.3

Lamb

104.8

Watson

Fantasy TE Rankings

84.4

McBride

82.7

Bowers

71.5

Likely

Fantasy K Rankings

90

Shrader

89

McLaughlin

83

Gay

NFL 2026 Betting

Best Record ATS

6-2

5-2

Worst Record ATS

0-6-1

1-7

2-7

2-5

2-4-1

3-5

NFL 2026 Standings

NFC East	W	L	T	PCT
Giants	4	2	1	.643
Cowboys	3	5	0	.375
Commanders	2	4	1	.357
Eagles	2	6	0	.250
NFC North	W	L	T	PCT
Vikings	6	1	0	.857
Bears	6	2	0	.750
Lions	5	2	0	.714
Packers	5	3	0	.625
NFC South	W	L	T	PCT
Panthers	3	4	0	.429
Buccaneers	3	5	0	.375
Falcons	3	5	0	.375
Saints	2	5	0	.286
NFC West	W	L	T	PCT
49ers	6	1	0	.857
Seahawks	4	4	0	.500
Rams	4	4	0	.500
Cardinals	3	5	0	.375

AFC East	W	L	T	PCT
Bills	6	1	0	.857
Patriots	5	3	0	.625
Jets	2	6	0	.250
Dolphins	1	6	0	.143
AFC North	W	L	T	PCT
Steelers	6	2	0	.750
Bengals	5	2	0	.714
Browns	5	3	0	.625
Ravens	4	5	0	.444
AFC South	W	L	T	PCT
Jaguars	6	2	0	.750
Texans	2	5	0	.286
Colts	2	6	0	.250
Titans	1	7	0	.125
AFC West	W	L	T	PCT
Broncos	6	2	0	.750
Chiefs	5	2	0	.714
Raiders	4	4	0	.500
Chargers	0	7	0	.000

NFL 2026 Scores & Schedule

Scores

DATE	MATCHUP			SCORE
Wed 9/9	NE	@	SEA	10-13
Thu 9/10	SF	@	LAR	27-7
Sun 9/13	CHI	@	CAR	59-37
Sun 9/13	BAL	@	IND	41-23
Sun 9/13	ATL	@	PIT	13-20

Schedule

DATE	MATCHUP			TIME (ET)
Sun 11/8	CIN	@	ATL	9:30 AM
Sun 11/8	DAL	@	IND	1:00 PM
Sun 11/8	LAR	@	WAS	1:00 PM
Sun 11/8	CLE	@	NO	1:00 PM
Sun 11/8	NYJ	@	KC	1:00 PM

O.J. Simpson has the most rushing yards for the Bills in a game, with 273 yards against the Lions on November 25, 1976.

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More Bills Stats

1,793

707

401

NFL 2026 Leaders

2,246

2,146

2,124

780

773

770

985

726

709

20

19

18

10

9

8

9

6

6

111.7

111.6

110.1

7.5

7.5

7.0

NFL 2026 Rankings

NFL Fantasy 2026

161.8

138.1

130.3

156

108.3

104.8

84.4

82.7

71.5

90

89

83

NFL 2026 Betting

NFL 2026 Standings

NFL 2026 Scores & Schedule

Scores

Schedule