Adrian Peterson has the most rushing yards in a game against the San Diego Chargers, with 296 yards on November 4, 2007.

most rushing yards vs chargers game
Interpreted as:
most rushing yards by a player vs chargers regular-season game
11/4/2007Peterson12/4/1966Granger11/4/2001Holmes11/30/1997Davis11/19/1995Davis9/8/2019Mack9/24/2017Hunt10/23/1988Dickerson9/15/1985Warner10/4/2009Mendenhall11/30/2003Holmes12/18/1966Garrett12/1/2002Portis12/20/2014Gore11/10/2011Bush12/16/2017Hunt12/20/2014Kaepernick10/27/1996Warren10/27/1974Green12/24/2017Powell12/15/2002Henry12/20/1964Daniels296183181178176174172169169165162161159158157155151146146145144144
NAMEDATETMOPPRUSH YDSATTRUSH AVGRUSH TDREC YDSRECTRGREC AVGREC TD
Adrian PetersonAdrian Peterson11/4/2007MINMINvs. SD
vs.
296309.93191219.00
Hoyle GrangerHoyle Granger12/4/1966HOUHOUvs. SD
vs.
183199.60321.50
Priest HolmesPriest Holmes11/4/2001KCKC@ SD
@
181306.019119.00
Terrell DavisTerrell Davis11/30/1997DENDEN@ SD
@
178266.813649.00
Terrell DavisTerrell Davis11/19/1995DENDENvs. SD
vs.
176305.9120210.00
Marlon MackMarlon Mack9/8/2019INDIND@ LAC
@
174257.010000
Kareem HuntKareem Hunt9/24/2017KCKC@ LAC
@
1721710.11111111.00
Eric DickersonEric Dickerson10/23/1988INDIND@ SD
@
169305.603047.50
Curt WarnerCurt Warner9/15/1985SEASEA@ SD
@
169286.023456.80
Rashard MendenhallRashard Mendenhall10/4/2009PITPITvs. SD
vs.
165295.72262213.00
Priest HolmesPriest Holmes11/30/2003KCKC@ SD
@
162315.2224456.00
Mike GarrettMike Garrett12/18/1966KCKC@ SD
@
161256.41-61-6.00
Clinton PortisClinton Portis12/1/2002DENDEN@ SD
@
159236.92343511.30
Frank GoreFrank Gore12/20/2014SFSFvs. SD
vs.
158266.110000
Michael BushMichael Bush11/10/2011OAKOAK@ SD
@
157305.21853428.30
Kareem HuntKareem Hunt12/16/2017KCKCvs. LAC
vs.
155246.5151797.31
Colin KaepernickColin Kaepernick12/20/2014SFSFvs. SD
vs.
151721.610000
Chris WarrenChris Warren10/27/1996SEASEAvs. SD
vs.
146197.7140410.00
Woody GreenWoody Green10/27/1974KCKC@ SD
@
146236.3198424.51
Bilal PowellBilal Powell12/24/2017NYJNYJvs. LAC
vs.
145197.610010
Travis HenryTravis Henry12/15/2002BUFBUFvs. SD
vs.
144226.520010
Clem DanielsClem Daniels12/20/1964OAKOAKvs. SD
vs.
144169.003348.30
Ricky WilliamsRicky Williams11/24/2002MIAMIAvs. SD
vs.
143294.928224.00
Chris JohnsonChris Johnson12/25/2009TENTENvs. SD
vs.
142216.81373412.30
Curt WarnerCurt Warner10/6/1986SEASEAvs. SD
vs.
142285.1034311.30
Results may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.

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