O.J. Simpson has rushed for the most yards in a Week-1 game, with 250 yards against the Patriots on September 16, 1973.
Interpreted as:
most rushing yards by a player week 1 ever| NAME | RUSH YDS | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | O.J. Simpson | 250 | 9/16/1973 | @ | 29 | 8.6 | 2 | 0 | 0 | 0 | ||||
| 2 |  | A. Foster | 231 | 9/12/2010 | vs | 33 | 7.0 | 3 | 7 | 1 | 1 | 7.0 | 0 | ||
| 3 | | M. Turner | 220 | 9/7/2008 | vs | 22 | 10.0 | 2 | 6 | 1 | 1 | 6.0 | 0 | ||
| 4 | | E. George | 216 | 8/31/1997 | vs | 35 | 6.2 | 1 | 0 | 0 | 0 | ||||
| 5 | | G. Rogers | 206 | 9/4/1983 | vs | 24 | 8.6 | 2 | 0 | 0 | 0 | ||||
| 6 | | G. Riggs | 202 | 9/2/1984 | @ | 35 | 5.8 | 2 | 0 | 0 | 0 | ||||
| 7 | | D. Staley | 201 | 9/3/2000 | @ | 26 | 7.7 | 1 | 61 | 4 | 7 | 15.3 | 0 | ||
| 8 | | N. Bulaich | 198 | 9/19/1971 | vs | 22 | 9.0 | 1 | 0 | 0 | 0 | ||||
| 9 |  | C. Martin | 196 | 9/12/2004 | vs | 29 | 6.8 | 1 | 7 | 3 | 3 | 2.3 | 1 | ||
| 10 | | A. Ameche | 194 | 9/25/1955 | vs | 21 | 9.2 | 1 | |||||||
| 11 |  | E. Dickerson | 193 | 9/7/1986 | @ | 38 | 5.1 | 2 | 0 | 0 | 0 | ||||
| 12 | | O. Anderson | 193 | 9/2/1979 | vs | 21 | 9.2 | 1 | 0 | 0 | 0 | ||||
| 13 | | G. Hearst | 187 | 9/6/1998 | vs | 20 | 9.4 | 2 | 38 | 2 | 19.0 | 0 | |||
| 14 |  | L. McCoy | 184 | 9/9/2013 | @ | 31 | 5.9 | 1 | 5 | 1 | 1 | 5.0 | 0 | ||
| 15 | | W. Galimore | 181 | 9/16/1962 | @ | 22 | 8.2 | 2 | 7 | 1 | 7.0 | 0 | |||
| 16 |  | A. Peterson | 180 | 9/13/2009 | @ | 25 | 7.2 | 3 | 18 | 1 | 1 | 18.0 | 0 | ||
| 17 | | C. Brown | 175 | 9/9/2007 | @ | 19 | 9.2 | 0 | 3 | 1 | 1 | 3.0 | 0 | ||
| 18 |  | M. Mack | 174 | 9/8/2019 | @ | 25 | 7.0 | 1 | 0 | 0 | 0 | 0 | |||
| 19 | | J. Jones | 174 | 9/7/1986 | @ | 36 | 4.8 | 1 | 0 | 0 | 0 | ||||
| 20 | | O.J. Simpson | 173 | 9/21/1975 | vs | 32 | 5.4 | 2 | 5 | 1 | 5.0 | 0 | |||
| 21 |  | E. Smith | 171 | 9/4/1994 | @ | 31 | 5.5 | 1 | 3 | 3 | 1.0 | 0 | |||
| 22 |  | J. Brown | 171 | 9/28/1958 | @ | 24 | 7.1 | 2 | |||||||
| 23 |  | D. Henry | 169 | 9/7/2025 | @ | 18 | 9.4 | 2 | 13 | 1 | 1 | 13.0 | 0 | ||
| 24 | | C.J. Spiller | 169 | 9/9/2012 | @ | 14 | 12.1 | 1 | 25 | 2 | 3 | 12.5 | 0 | ||
| 25 | | R. Smith | 169 | 8/31/1997 | @ | 16 | 10.6 | 1 | 5 | 1 | 5.0 | 0 | |||
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WASResults may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.
More Bills Stats
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Team Rankings
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159.6
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| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
