Between the 2000 and 2009 seasons, Osi Umenyiora had the most sacks in a game, with 6 sacks against the Eagles on September 30, 2007.

Interpreted as:

most defensive sacks by a player ever in a regular-season game in 2000s

	NAME	SCK	DATE	TM		OPP	TKL	AST	COMB	SCKY	INT	INT YDS	INT TD	FF	FR	FR TD
1	Osi Umenyiora O. Umenyiora	6.0	9/30/2007	NYG	vs	PHI	6	0	6	38	0	0	0	2	0	0
2	Antwan Odom A. Odom	5.0	9/20/2009	CIN	@	GB	6	0	6	31	0	0	0	0	0	0
3	Vonnie Holliday V. Holliday	5.0	12/22/2002	GB	vs	BUF	5	2	7	28	0	0	0	3	0	0
4	Jared Allen J. Allen	4.5	10/5/2009	MIN	vs	GB	6	1	7	19.5	0	0	0	1	0	0
5	Brian Orakpo B. Orakpo	4.0	12/13/2009	WAS	@	OAK	5	1	6	44	0	0	0	1	0	0
6	Elvis Dumervil E. Dumervil	4.0	9/20/2009	DEN	vs	CLE	7	0	7	15	0	0	0	1	0	0
7	Kevin Williams K. Williams	4.0	10/12/2008	MIN	vs	DET	8	0	8	28	0	0	0	0	0	0
8	Joey Porter J. Porter	4.0	9/21/2008	MIA	@	NE	5	1	6	15	0	0	0	1	0	0
9	Darryl Tapp D. Tapp	4.0	10/21/2007	SEA	vs	STL	5	0	5	26	0	0	0	1	0	0
10	Phillip Daniels P. Daniels	4.0	12/18/2005	WAS	vs	DAL	5	0	5	19	0	0	0	0	1	0
11	Kabeer Gbaja-Biamila K. Gbaja-Biamila	4.0	1/2/2005	GB	@	CHI	6	1	7	23	0	0	0	1	0	0
12	Bertrand Berry B. Berry	4.0	11/14/2004	ARI	vs	NYG	7	0	7	22	0	0	0	0	0	0
13	Alex Brown A. Brown	4.0	11/7/2004	CHI	@	NYG	6	2	8	18	0	0	0	1	0	0
14	Leonard Little L. Little	4.0	11/30/2003	STL	vs	MIN	5	1	6	25	0	0	0	2	0	0
15	Andra Davis A. Davis	4.0	11/9/2003	CLE	@	KC	11	2	13	20	0	0	0	1	0	0
16	Simeon Rice S. Rice	4.0	10/12/2003	TB	@	WAS	6	0	6	34	0	0	0	1	1	0
17	Peter Boulware P. Boulware	4.0	1/7/2002	BAL	vs	MIN	5	2	7	20	0	0	0	1	0	0
18	John Abraham J. Abraham	4.0	11/4/2001	NYJ	@	NO	5	0	5	15	0	0	0	0	0	0
19	Joey Porter J. Porter	4.0	10/21/2001	PIT	@	TB	6	0	6	29	0	0	0	0	0	0
20	Michael Strahan M. Strahan	4.0	10/14/2001	NYG	@	STL	6	0	6	28	0	0	0	1	0	0
21	Marcus Jones M. Jones	4.0	10/19/2000	TB	vs	DET					0	0	0			0
22	Justin Smith J. Smith	3.5	1/3/2010	SF	@	STL	8	0	8	30	0	0	0	0	0	0
23	Jason Jones J. Jones	3.5	12/21/2008	TEN	vs	PIT	4	1	5	22	0	0	0	3	0	0
24	Mario Williams M. Williams	3.5	12/13/2007	HOU	vs	DEN	5	2	7	14	0	0	0	0	0	0
25	James Harrison J. Harrison	3.5	11/5/2007	PIT	vs	BAL	9	1	10	25.5	1	20	0	3	1	0

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Interpreted as:

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