I didn't find anything for this season, but the Buffalo Bills were targeted their most times in a game in 2025 versus the Ravens on September 7, with 45 targets.
Interpreted as:
most targets in a regular-season game buffalo bills this season| TEAM | TRG | DATE | TM | OPP | REC | REC YDS | AVG | REC TD | RUSH YDS | ATT | YPC | RUSH TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 45 | 9/7/2025 | vs | 33 | 394 | 11.9 | 2 | 108 | 31 | 3.5 | 3 | ||
| 2 | | Bills | 39 | 11/9/2025 | @ | 28 | 306 | 10.9 | 2 | 87 | 22 | 4.0 | 0 | ||
| 3 | | Bills | 33 | 12/28/2025 | vs | 23 | 262 | 11.4 | 0 | 120 | 33 | 3.6 | 2 | ||
| 4 | | Bills | 32 | 11/20/2025 | @ | 24 | 253 | 10.5 | 0 | 143 | 24 | 6.0 | 1 | ||
| 5 | | Bills | 30 | 11/16/2025 | vs | 19 | 317 | 16.7 | 3 | 97 | 23 | 4.2 | 3 | ||
| 6 | | Bills | 30 | 10/5/2025 | vs | 22 | 253 | 11.5 | 2 | 118 | 29 | 4.1 | 0 | ||
| 7 | | Bills | 28 | 1/4/2026 | vs | 22 | 259 | 11.8 | 4 | 211 | 43 | 4.9 | 1 | ||
| 8 | | Bills | 27 | 12/7/2025 | vs | 22 | 251 | 11.4 | 3 | 183 | 29 | 6.3 | 1 | ||
| 9 | | Bills | 27 | 9/18/2025 | vs | 22 | 213 | 9.7 | 3 | 157 | 27 | 5.8 | 1 | ||
| 10 | | Bills | 26 | 12/14/2025 | @ | 19 | 193 | 10.2 | 3 | 168 | 37 | 4.5 | 2 | ||
| 11 | | Bills | 26 | 10/13/2025 | @ | 15 | 180 | 12.0 | 2 | 134 | 24 | 5.6 | 0 | ||
| 12 | | Bills | 25 | 11/2/2025 | vs | 23 | 273 | 11.9 | 1 | 141 | 35 | 4.0 | 3 | ||
| 13 | | Bills | 25 | 9/14/2025 | @ | 15 | 180 | 12.0 | 0 | 224 | 43 | 5.2 | 3 | ||
| 14 | | Bills | 23 | 11/30/2025 | @ | 15 | 123 | 8.2 | 1 | 249 | 51 | 4.9 | 1 | ||
| 15 | | Bills | 23 | 10/26/2025 | @ | 14 | 185 | 13.2 | 1 | 245 | 35 | 7.0 | 4 | ||
| 16 | | Bills | 22 | 9/28/2025 | vs | 16 | 209 | 13.1 | 2 | 165 | 32 | 5.2 | 2 | ||
| 17 | | Bills | 18 | 12/21/2025 | @ | 12 | 130 | 10.8 | 0 | 164 | 29 | 5.7 | 3 |
StatMuse has game-level data for targets going back to the 1999 season.
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More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |