Randy Moss got his most total touchdowns in a game against the Bills on November 18, 2007, with 4 touchdowns.

most td by randy moss in a game
Interpreted as:
most td by Randy Moss in a regular-season game
11/18/2007Moss12/27/2009Moss10/18/2009Moss11/23/2008Moss9/28/2003Moss11/19/2001Moss10/1/2000Moss12/6/1998Moss11/26/1998Moss9/26/2010Moss11/15/2009Moss12/14/2008Moss10/20/2008Moss12/29/2007Moss12/23/2007Moss12/9/2007Moss10/21/2007Moss10/1/2007Moss9/23/2007Moss9/16/2007Moss12/31/2005Moss433333333222222222222
Results may be incomplete. StatMuse has complete game-level data for touchdowns going back to the 1950 season.

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