| NAME | GP | TKL | AST | COMB | SCK | SCKY | INT | INT YDS | INT TD | FF | FR | FR TD | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| London Fletcher | 144 | 876 | 377 | 1,253 | 21.5 | 131.5 | 11 | 106 | 2 | 11 | 9 | 1 |
 | Keith Brooking | 144 | 841 | 243 | 1,084 | 17.0 | 116.5 | 11 | 132 | 0 | 5 | 10 | 0 |
| Lavonte David | 137 | 806 | 319 | 1,125 | 24.0 | 170 | 12 | 169 | 2 | 24 | 16 | 1 |
| Lance Briggs | 140 | 795 | 178 | 973 | 10.5 | 59.5 | 13 | 144 | 3 | 14 | 7 | 1 |
| Keith Bulluck | 141 | 763 | 280 | 1,043 | 18.0 | 118.5 | 18 | 184 | 0 | 14 | 12 | 4 |
 | Ray Lewis | 118 | 760 | 292 | 1,052 | 20.5 | 139 | 19 | 332 | 2 | 12 | 12 | 0 |
| Donnie Edwards | 119 | 754 | 256 | 1,010 | 11.0 | 67.5 | 18 | 215 | 2 | 10 | 6 | 1 |
| Paul Posluszny | 113 | 742 | 278 | 1,020 | 13.0 | 78 | 14 | 145 | 1 | 8 | 3 | 0 |
| Chad Greenway | 140 | 735 | 326 | 1,061 | 18.0 | 92 | 10 | 205 | 2 | 8 | 11 | 0 |
| Patrick Willis | 112 | 733 | 217 | 950 | 20.5 | 130.5 | 8 | 131 | 2 | 16 | 5 | 0 |
| Bobby Wagner | 135 | 726 | 487 | 1,213 | 22.5 | 149 | 10 | 184 | 1 | 5 | 9 | 3 |
| Derrick Johnson | 137 | 724 | 149 | 873 | 22.5 | 148 | 11 | 277 | 3 | 20 | 7 | 0 |
| James Farrior | 140 | 715 | 328 | 1,043 | 23.0 | 168.5 | 10 | 225 | 1 | 14 | 9 | 0 |
 | Brian Urlacher | 122 | 715 | 227 | 942 | 29.5 | 184 | 15 | 252 | 1 | 8 | 8 | 1 |
| Karlos Dansby | 136 | 711 | 179 | 890 | 31.5 | 217 | 11 | 160 | 2 | 15 | 9 | 0 |
| DeMeco Ryans | 126 | 703 | 218 | 921 | 13.5 | 123.5 | 6 | 63 | 0 | 6 | 9 | 1 |
| D'Qwell Jackson | 129 | 702 | 412 | 1,114 | 18.5 | 102 | 9 | 91 | 2 | 7 | 11 | 1 |
 | Luke Kuechly | 118 | 690 | 402 | 1,092 | 12.5 | 73 | 18 | 153 | 1 | 7 | 9 | 1 |
| Eric Weddle | 137 | 683 | 168 | 851 | 6.5 | 31.5 | 19 | 290 | 3 | 5 | 6 | 1 |
| Zach Thomas | 110 | 682 | 400 | 1,082 | 13.5 | 91.5 | 8 | 75 | 1 | 9 | 5 | 0 |
| Derrick Brooks | 128 | 681 | 218 | 899 | 8.0 | 30 | 16 | 391 | 5 | 11 | 1 | 1 |
| Will Witherspoon | 143 | 673 | 161 | 834 | 23.0 | 163 | 11 | 115 | 2 | 9 | 5 | 0 |
| James Laurinaitis | 117 | 664 | 207 | 871 | 16.5 | 120.5 | 10 | 74 | 0 | 2 | 9 | 0 |
| Curtis Lofton | 128 | 660 | 288 | 948 | 8.0 | 62 | 3 | 32 | 1 | 11 | 5 | 0 |
| Antoine Winfield | 127 | 655 | 96 | 751 | 4.0 | 32 | 18 | 157 | 2 | 11 | 9 | 1 |