The San Francisco 49ers are 41-41-6 against the spread as underdogs in the regular season on the road from 2007 through 2026.
Showing
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/16/2007 | 1-0 | +140 | @ | -160 | W 17-16 | +3 | +4 (Y) | 44 | -11 (U) | 2 | 8 | 186 | 392 | 23.1 | 100.0 | ||
| 2 | | 49ers | 9/23/2007 | 0-1 | +450 | @ | -600 | L 16-37 | +9.5 | -11.5 (N) | 37.5 | +15.5 (O) | 1 | 17 | 289 | 350 | 33.3 | 0.0 | ||
| 3 | | 49ers | 10/21/2007 | 0-1 | +375 | @ | -475 | L 15-33 | +9.5 | -8.5 (N) | 39 | +9 (O) | 2 | 20 | 267 | 279 | 30.8 | 100.0 | ||
| 4 | | 49ers | 11/4/2007 | 0-1 | +175 | @ | -200 | L 16-20 | +3.5 | -0.5 (N) | 37 | -1 (U) | 1 | 16 | 251 | 286 | 23.1 | |||
| 5 | | 49ers | 11/12/2007 | 0-1 | +320 | @ | -420 | L 0-24 | +9.5 | -14.5 (N) | 38.5 | -14.5 (U) | 0 | 6 | 173 | 380 | 8.3 | 0.0 | ||
| 6 | | 49ers | 11/25/2007 | 1-0 | +450 | @ | -625 | W 37-31 | +10.5 | +16.5 (Y) | 37.5 | +30.5 (O) | 5 | 21 | 374 | 552 | 30.8 | 0.0 | ||
| 7 | | 49ers | 12/2/2007 | 0-1 | +145 | @ | -165 | L 14-31 | +3 | -14 (N) | 35.5 | +9.5 (O) | 2 | 12 | 195 | 323 | 27.3 | 0.0 | ||
| 8 | | 49ers | 12/30/2007 | 0-1 | +475 | @ | -650 | L 7-20 | +11.5 | -1.5 (N) | 40.5 | -13.5 (U) | 1 | 9 | 185 | 358 | 28.6 | 0.0 | ||
| 9 | | 49ers | 9/14/2008 | 1-0 | +240 | @ | -285 | W 33-30 | +6.5 | +9.5 (Y) | 38 | +25 (O) | 3 | 20 | 365 | 351 | 35.7 | |||
| 10 | | 49ers | 9/28/2008 | 0-1 | +175 | @ | -205 | L 17-31 | +4.5 | -9.5 (N) | 48 | 0 (P) | 1 | 20 | 312 | 467 | 30.0 | 100.0 | ||
| 11 | | 49ers | 10/19/2008 | 0-0-1 | +375 | @ | -475 | L 17-29 | +12 | 0 (P) | 45 | +1 (O) | 2 | 13 | 253 | 273 | 20.0 | 0.0 | ||
| 12 | | 49ers | 11/10/2008 | 1-0 | +340 | @ | -440 | L 24-29 | +9.5 | +4.5 (Y) | 46 | +7 (O) | 3 | 19 | 336 | 374 | 50.0 | |||
| 13 | | 49ers | 11/23/2008 | 0-1 | +350 | @ | -450 | L 22-35 | +9.5 | -3.5 (N) | 46 | +11 (O) | 2 | 16 | 304 | 408 | 20.0 | |||
| 14 | | 49ers | 11/30/2008 | 1-0 | +245 | @ | -290 | W 10-3 | +6.5 | +13.5 (Y) | 43 | -30 (U) | 1 | 12 | 195 | 350 | 46.7 | |||
| 15 | | 49ers | 12/14/2008 | 1-0 | +210 | @ | -250 | L 9-14 | +6 | +1 (Y) | 41.5 | -18.5 (U) | 0 | 24 | 318 | 248 | 47.1 | 0.0 | ||
| 16 | | 49ers | 9/13/2009 | 1-0 | +190 | @ | -230 | W 20-16 | +6 | +10 (Y) | 46 | -10 (U) | 2 | 13 | 203 | 299 | 38.9 | |||
| 17 | | 49ers | 9/27/2009 | 1-0 | +240 | @ | -280 | L 24-27 | +6.5 | +3.5 (Y) | 39.5 | +11.5 (O) | 3 | 13 | 246 | 377 | 0.0 | 100.0 | ||
| 18 | | 49ers | 10/25/2009 | 0-0-1 | +160 | @ | -185 | L 21-24 | +3 | 0 (P) | 44.5 | +0.5 (O) | 3 | 17 | 297 | 336 | 36.4 | 0.0 | ||
| 19 | | 49ers | 11/1/2009 | 1-0 | +550 | @ | -800 | L 14-18 | +12.5 | +8.5 (Y) | 44.5 | -12.5 (U) | 2 | 16 | 295 | 410 | 20.0 | |||
| 20 | | 49ers | 11/22/2009 | 0-0-1 | +220 | @ | -265 | L 24-30 | +6 | 0 (P) | 42 | +12 (O) | 3 | 11 | 284 | 484 | 27.3 | 50.0 | ||
| 21 | | 49ers | 12/20/2009 | 0-1 | +280 | @ | -350 | L 13-27 | +7 | -7 (N) | 40.5 | -0.5 (U) | 1 | 13 | 261 | 422 | 0.0 | 75.0 | ||
| 22 | | 49ers | 10/3/2010 | 1-0 | +260 | @ | -315 | L 14-16 | +7 | +5 (Y) | 42.5 | -12.5 (U) | 2 | 17 | 262 | 357 | 50.0 | 100.0 | ||
| 23 | | 49ers | 12/5/2010 | 0-1 | +350 | @ | -450 | L 16-34 | +9 | -9 (N) | 41 | +9 (O) | 1 | 11 | 269 | 410 | 25.0 | 100.0 | ||
| 24 | | 49ers | 12/16/2010 | 0-1 | +450 | @ | -600 | L 7-34 | +9.5 | -17.5 (N) | 44.5 | -3.5 (U) | 1 | 11 | 192 | 374 | 16.7 | 0.0 | ||
| 25 | | 49ers | 12/26/2010 | 0-1 | +120 | @ | -140 | L 17-25 | +2.5 | -5.5 (N) | 40 | +2 (O) | 2 | 12 | 331 | 335 | 25.0 | 100.0 | ||
| Average | 0.6 | 2.1 | 17.7 | 313.5 | 366.3 | 33.2 | 0.0 | |||||||||||||
| Total | 41-41-6 | 183 | 1,554 | 27,591 | 32,235 | 33.2 | 50.0 | |||||||||||||
SF
STL
PIT
NYG
ATL
SEA
ARI
CAR
CLE
NO
DAL
BUF
MIA
MIN
HOU
IND
GB
PHI
SDMore NFL News
Patriots rule out A.J. Brown, TreVeyon Henderson and Marcus Bryant vs. Dolphins
Other women contacted police about previous incidents with Packers' Josh Jacobs after his arrest
Commanders defensive tackle Daron Payne suffers foot injury, AP source says
Bengals getting impact play from Amarius Mims, Ted Karras and the offensive line
Acquiring Jeffery Simmons like 'Christmas morning' for the Chicago Bears
Injuries beginning to take their toll on the Panthers' secondary, offensive line
More 49ers Stats
Team Leaders 
PASS
1,748
Purdy
RUSH
389
McCaffrey
REC
425
Kittle
Team Rankings
PPG
28.1
3rd
OPP PPG
19.9
6th
RUSH YDS/G
127.4
8th
PASS YDS/G
249.7
12th
Rams
LV
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
4 | 2 | 1 | .643 | |
3 | 4 | 0 | .429 | |
2 | 5 | 0 | .286 | |
1 | 4 | 1 | .250 | |
| NFC North | W | L | T | PCT |
6 | 0 | 0 | 1.000 | |
5 | 2 | 0 | .714 | |
4 | 2 | 0 | .667 | |
5 | 3 | 0 | .625 | |
| NFC South | W | L | T | PCT |
3 | 4 | 0 | .429 | |
3 | 4 | 0 | .429 | |
2 | 5 | 0 | .286 | |
2 | 5 | 0 | .286 | |
| NFC West | W | L | T | PCT |
6 | 1 | 0 | .857 | |
4 | 3 | 0 | .571 | |
3 | 4 | 0 | .429 | |
2 | 5 | 0 | .286 |
Commanders
Bears
Lions
Buccaneers| AFC East | W | L | T | PCT |
|---|---|---|---|---|
5 | 1 | 0 | .833 | |
4 | 3 | 0 | .571 | |
2 | 5 | 0 | .286 | |
1 | 5 | 0 | .167 | |
| AFC North | W | L | T | PCT |
5 | 2 | 0 | .714 | |
5 | 2 | 0 | .714 | |
4 | 2 | 0 | .667 | |
4 | 3 | 0 | .571 | |
| AFC South | W | L | T | PCT |
4 | 2 | 0 | .667 | |
2 | 5 | 0 | .286 | |
2 | 5 | 0 | .286 | |
1 | 6 | 0 | .143 | |
| AFC West | W | L | T | PCT |
5 | 1 | 0 | .833 | |
5 | 2 | 0 | .714 | |
3 | 4 | 0 | .429 | |
0 | 6 | 0 | .000 |
Patriots
Jets
Bengals
Ravens
Jaguars
Titans
Chiefs
Broncos