niners record against bills

The San Francisco 49ers have a record of 6-8 against the Bills all-time.

TEAMDATERECTMOPPRESULTW%TD1DWNOFFOPP OFF3DWN%4DWN%
149ers
49ers
9/24/1972
0-1
@
L
20-27
.000
2
10
202
233
249ers
49ers
12/21/1980
0-1
vs
L
13-18
.000
2
19
298
267
349ers
49ers
12/11/1983
1-0
@
W
23-10
1.000
2
19
310
303
449ers
49ers
12/17/1989
1-0
vs
W
21-10
1.000
3
18
283
301
549ers
49ers
9/13/1992
0-1
vs
L
31-34
.000
4
26
598
488
61.5
100.0
649ers
49ers
12/3/1995
1-0
vs
W
27-17
1.000
3
18
323
275
31.3
50.0
749ers
49ers
10/4/1998
0-1
@
L
21-26
.000
3
23
377
352
46.2
849ers
49ers
12/2/2001
1-0
vs
W
35-0
1.000
5
26
409
191
66.7
0.0
949ers
49ers
12/26/2004
0-1
vs
L
7-41
.000
1
12
189
441
30.0
100.0
1049ers
49ers
11/30/2008
1-0
@
W
10-3
1.000
1
12
195
350
46.7
1149ers
49ers
10/7/2012
1-0
vs
W
45-3
1.000
6
29
621
204
63.6
100.0
1249ers
49ers
10/16/2016
0-1
@
L
16-45
.000
1
16
300
492
23.1
0.0
1349ers
49ers
12/7/2020
0-1
vs
L
24-34
.000
3
24
402
449
54.5
0.0
1449ers
49ers
12/1/2024
0-1
@
L
10-35
.000
1
15
239
372
30.0
100.0
Average.4292.619.1339.0337.0
Total6-8.429372674,7464,718

More 49ers Stats

Team Leaders

PASS

2,167

Purdy

Brock Purdy

RUSH

1,202

McCaffrey

Christian McCaffrey

REC

924

McCaffrey

Christian McCaffrey
Team Rankings

PPG

25.7

10th

OPP PPG

21.8

13th

RUSH YDS/G

106.9

24th

PASS YDS/G

254.0

6th

2025 Division Standings
TEAMWLTPCT
14
3
0
.824
12
5
0
.706
49ers 49ers
12
5
0
.706
3
14
0
.176
Schedule
DATEMATCHUPTIME (ET)
Sun
1/11
@
4:30 PM
Last Game
SEA Seahawks

14 - 3

13

Final

3

SF 49ers

12 - 5

Sat 3 Jan 2026

NFL 2025 Leaders

NFL 2025 Rankings

NFL Fantasy 2025

NFL 2025 Betting

NFL 2025 Standings

AFC EastWLTPCT
14
3
0
.824
Bills Bills - w
12
5
0
.706
7
10
0
.412
Jets Jets - e
3
14
0
.176
AFC NorthWLTPCT
10
7
0
.588
8
9
0
.471
6
11
0
.353
5
12
0
.294
AFC SouthWLTPCT
13
4
0
.765
12
5
0
.706
Colts Colts - e
8
9
0
.471
3
14
0
.176
AFC WestWLTPCT
14
3
0
.824
11
6
0
.647
6
11
0
.353
3
14
0
.176
NFC EastWLTPCT
11
6
0
.647
7
9
1
.441
5
12
0
.294
4
13
0
.235
NFC NorthWLTPCT
Bears Bears - y
11
6
0
.647
9
7
1
.559
9
8
0
.529
Lions Lions - e
9
8
0
.529
NFC SouthWLTPCT
8
9
0
.471
8
9
0
.471
8
9
0
.471
6
11
0
.353
NFC WestWLTPCT
14
3
0
.824
Rams Rams - w
12
5
0
.706
49ers 49ers - w
12
5
0
.706
3
14
0
.176

NFL 2025 Scores & Schedule

Scores

DATEMATCHUPSCORE
Sat
10/4
@
22-21
Sat
10/4
@
38-35
Sat
10/4
@
37-24
Sat
10/4
@
27-10
Sat
10/4
@
23-20

Schedule

DATEMATCHUPTIME (ET)
Sat
1/10
@
4:30 PM
Sat
1/10
@
8:00 PM
Sun
1/11
@
1:00 PM
Sun
1/11
@
4:30 PM
Sun
1/11
@
8:00 PM