| TEAM | OPPONENT | WEEK/ROUND | DATE | TIME (ET) | SPREAD | OVER/UNDER | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Buffalo Bills | -226 | @ |  Atlanta Falcons | +185 | WK 6 | Mon, Oct 13, 2025 | 7:15 PM | -4.5 | 50.0 |
| 2 | | Buffalo Bills | -333 | @ |  Carolina Panthers | +245 | WK 8 | Sun, Oct 26, 2025 | 1:00 PM | -7.0 | 48.5 |
| 3 | | Buffalo Bills | -149 | vs |  Kansas City Chiefs | +120 | WK 9 | Sun, Nov 2, 2025 | 4:25 PM | -2.5 | 48.0 |
| 4 | | Buffalo Bills | -238 | @ |  Miami Dolphins | +190 | WK 10 | Sun, Nov 9, 2025 | 1:00 PM | -5.5 | 49.5 |
| 5 | | Buffalo Bills | -238 | vs |  Tampa Bay Buccaneers | +190 | WK 11 | Sun, Nov 16, 2025 | 1:00 PM | -6.0 | 50.5 |
| 6 | | Buffalo Bills | -227 | @ |  New England Patriots | +175 | WK 15 | Sun, Dec 14, 2025 | 1:00 PM | -5.5 | 47.5 |
Betting lines shown represent consensus, closing odds.
More Bills Stats
Team Rankings
PPG
30.6
3rd
OPP PPG
22.6
17th
RUSH YDS/G
154.4
2nd
PASS YDS/G
249.8
11th
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NFL 2025 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 4 | 2 | 0 | .667 |
 Commanders | 3 | 2 | 0 | .600 |
| NFC North | W | L | T | PCT |
 Lions | 4 | 1 | 0 | .800 |
 Packers | 2 | 1 | 1 | .625 |
| NFC South | W | L | T | PCT |
| Buccaneers | 4 | 1 | 0 | .800 |
| Falcons | 2 | 2 | 0 | .500 |
| NFC West | W | L | T | PCT |
 49ers | 4 | 1 | 0 | .800 |
 Seahawks | 3 | 2 | 0 | .600 |
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