The Carolina Panthers have a record of 1-3 in the regular-season and playoffs versus the Bills at home all-time.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Panthers | 10/25/1998 | 0-1 |  CAR | vs |  BUF | L 14-30 | .000 | 2 | 21 | 360 | 426 | 42.9 | 66.7 |
| 2 | | Panthers | 10/25/2009 | 0-1 | CAR | vs | BUF | L 9-20 | .000 | 1 | 20 | 425 | 167 | 15.4 | 66.7 |
| 3 | | Panthers | 9/17/2017 | 1-0 | CAR | vs | BUF | W 9-3 | 1.000 | 0 | 19 | 255 | 176 | 43.8 | |
| 4 | | Panthers | 10/26/2025 | 0-1 | CAR | vs | BUF | L 9-40 | .000 | 1 | 19 | 244 | 410 | 36.4 | 100.0 |
| Average | .250 | 1.0 | 19.8 | 321.0 | 294.8 | 35.2 | 23.8 | ||||||||
| Total | 1-3 | .250 | 4 | 79 | 1,284 | 1,179 | 35.2 | 71.4 |
More Panthers Stats
Team Rankings
PPG
18.9
27th
OPP PPG
22.8
17th
RUSH YDS/G
139.8
4th
PASS YDS/G
187.0
31st
2025 Division Standings
| TEAM | W | L | T | PCT |
|---|---|---|---|---|
 Buccaneers | 6 | 2 | 0 | .750 |
| Panthers | 5 | 4 | 0 | .556 |
 Falcons | 3 | 5 | 0 | .375 |
 Saints | 1 | 7 | 0 | .125 |
SF
LAR
Patriots
Steelers
Ravens
Colts
Jaguars
Broncos
Chargers
Eagles
Cowboys
Packers
Lions
Seahawks
KC
NYJ
LV
WAS
ARI
