O.J. Simpson has rushed for the most yards for the Bills in a game, with 273 yards against the Lions on November 25, 1976.
Interpreted as:
top 3 or more rush yards leaders in a regular-season game for the buffalo bills| NAME | RUSH YDS | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | O.J. Simpson | 273 | 11/25/1976 | @ | 29 | 9.4 | 2 | 0 | 0 | 0 | ||||
| 2 | | O.J. Simpson | 250 | 9/16/1973 | @ | 29 | 8.6 | 2 | 0 | 0 | 0 | ||||
| 3 |  | C. Gilchrist | 243 | 12/8/1963 | vs | 36 | 6.8 | 5 | 0 | 0 | 0 | ||||
| 4 | | O.J. Simpson | 227 | 9/28/1975 | @ | 28 | 8.1 | 1 | 0 | 0 | 0 | ||||
| 5 | | O.J. Simpson | 219 | 12/9/1973 | vs | 22 | 10.0 | 1 | 0 | 0 | 0 | ||||
| 6 |  | J. Cook III | 216 | 10/26/2025 | @ | 19 | 11.4 | 2 | 0 | 0 | 0 | 0 | |||
| 7 | | T. Thomas | 214 | 9/24/1990 | @ | 18 | 11.9 | 0 | 5 | 3 | 1.7 | 0 | |||
| 8 | | F. Jackson | 212 | 1/3/2010 | vs | 33 | 6.4 | 0 | 15 | 2 | 2 | 7.5 | 1 | ||
| 9 | | T. Miller | 208 | 11/26/1978 | vs | 21 | 9.9 | 2 | 7 | 2 | 3.5 | 0 | |||
| 10 | | G. Bell | 206 | 11/18/1984 | vs | 27 | 7.6 | 1 | 12 | 2 | 6.0 | 1 | |||
| 11 | | O.J. Simpson | 203 | 12/5/1976 | @ | 24 | 8.5 | 1 | 12 | 2 | 6.0 | 0 | |||
| 12 | | O.J. Simpson | 200 | 12/16/1973 | @ | 34 | 5.9 | 1 | 0 | 0 | 0 | ||||
| 13 | | O.J. Simpson | 197 | 11/17/1975 | @ | 17 | 11.6 | 2 | 21 | 2 | 10.5 | 0 | |||
| 14 | | O.J. Simpson | 189 | 10/29/1972 | vs | 22 | 8.6 | 1 | 7 | 3 | 2.3 | 0 | |||
| 15 | | J. Cribbs | 185 | 12/4/1983 | @ | 36 | 5.1 | 0 | 0 | 0 | 0 | ||||
| 16 | | O.J. Simpson | 185 | 12/14/1975 | @ | 21 | 8.8 | 1 | 28 | 2 | 14.0 | 0 | |||
| 17 | | K. Davis | 181 | 11/22/1992 | vs | 20 | 9.1 | 2 | 4 | 1 | 4.0 | 0 | |||
| 18 | | J. Cook III | 179 | 12/17/2023 | vs | 25 | 7.2 | 1 | 42 | 2 | 3 | 21.0 | 1 | ||
| 19 | | O.J. Simpson | 173 | 9/21/1975 | vs | 32 | 5.4 | 2 | 5 | 1 | 5.0 | 0 | |||
| 20 | | O.J. Simpson | 171 | 12/12/1976 | @ | 28 | 6.1 | 1 | 18 | 1 | 18.0 | 0 | |||
| 21 | | O.J. Simpson | 171 | 10/7/1973 | vs | 27 | 6.3 | 1 | 33 | 3 | 11.0 | 0 | |||
| 22 | | C.J. Spiller | 169 | 9/9/2012 | @ | 14 | 12.1 | 1 | 25 | 2 | 3 | 12.5 | 0 | ||
| 23 | | T. Henry | 169 | 12/7/2003 | vs | 32 | 5.3 | 1 | 6 | 1 | 1 | 6.0 | 0 | ||
| 24 | | T. Henry | 167 | 10/19/2003 | vs | 31 | 5.4 | 2 | 13 | 1 | 2 | 13.0 | 0 | ||
| 25 | | J. Cribbs | 166 | 9/25/1983 | vs | 22 | 7.5 | 1 | 0 | 0 | 0 | ||||
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HOUResults may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.
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More Bills Stats
Team Leaders 
PASS
334
Allen
RUSH
57
Cook
REC
130
Kincaid
Team Rankings
PPG
36.0
5th
OPP PPG
31.0
22nd
RUSH YDS/G
86.0
24th
PASS YDS/G
334.0
4th
LAC
LAR
LV
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NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
| NFC North | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
| NFC South | W | L | T | PCT |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
| NFC West | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 |
Commanders
Vikings
Bears
Packers
Buccaneers
Saints
49ers
Cardinals
Seahawks| AFC East | W | L | T | PCT |
|---|---|---|---|---|
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
| AFC North | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
| AFC South | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
| AFC West | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 1 | 0 | .000 |
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