Warren Moon has the most passing yards in a Week-15 game, with 527 yards against the Chiefs on December 16, 1990.

Interpreted as:

top 5 passing by a player week 15

	NAME	YDS	DATE	TM		OPP	CMP	ATT	PCT	AVG	TD	INT	RTG	TD%	INT%	SCK	SCKY
1	Warren Moon W. Moon	527	12/16/1990	HOU	@	KC	27	45	60.0	11.7	3	0	123.1	6.7	0.0	3	22
2	Ben Roethlisberger B. Roethlisberger	503	12/20/2009	PIT	vs	GB	29	46	63.0	10.9	3	0	121.9	6.5	0.0	5	31
3	Jared Goff J. Goff	494	12/15/2024	DET	vs	BUF	38	59	64.4	8.4	5	0	118.9	8.5	0.0	3	21
4	Billy Volek B. Volek	492	12/19/2004	TEN	@	OAK	40	60	66.7	8.2	4	1	107.1	6.7	1.7	3	26
5	Kirk Cousins K. Cousins	460	12/17/2022	MIN	vs	IND	34	54	63.0	8.5	4	2	99.3	7.4	3.7	7	34
6	Jameis Winston J. Winston	458	12/15/2019	TB	@	DET	28	42	66.7	10.9	4	1	124.9	9.5	2.4	2	12
7	Tommy Kramer T. Kramer	456	12/14/1980	MIN	vs	CLE	38	49	77.6	9.3	4	0	132.7	8.2	0.0
8	Tom Brady T. Brady	443	12/16/2012	NE	vs	SF	36	65	55.4	6.8	1	2	68.9	1.5	3.1	3	18
9	Dan Fouts D. Fouts	435	12/20/1982	SD	vs	CIN	25	40	62.5	10.9	1	2	87.0	2.5	5.0	2	15
10	Eli Manning E. Manning	434	12/17/2017	NYG	vs	PHI	37	57	64.9	7.6	3	1	98.1	5.3	1.8	1	5
11	Chris Chandler C. Chandler	431	12/23/2001	ATL	vs	BUF	28	40	70.0	10.8	2	2	101.1	5.0	5.0	1	9
12	Nick Foles N. Foles	428	12/15/2013	PHI	@	MIN	30	48	62.5	8.9	3	1	103.5	6.3	2.1	4	32
13	Ken Anderson K. Anderson	416	12/20/1982	CIN	@	SD	40	56	71.4	7.4	2	1	97.0	3.6	1.8	3	19
14	Drew Brees D. Brees	412	12/18/2011	NO	@	MIN	32	40	80.0	10.3	5	0	149.2	12.5	0.0	0	0
15	Bill Kenney B. Kenney	411	12/11/1983	KC	@	SD	31	41	75.6	10.0	4	1	129.2	9.8	2.4	1	5
16	Patrick Mahomes P. Mahomes	410	12/16/2021	KC	@	LAC	31	47	66.0	8.7	3	1	105.8	6.4	2.1	1	0
17	Kyler Murray K. Murray	406	12/20/2020	ARI	vs	PHI	27	36	75.0	11.3	3	1	127.8	8.3	2.8	1	9
18	Daunte Culpepper D. Culpepper	404	12/19/2004	MIN	@	DET	25	35	71.4	11.5	3	1	126.4	8.6	2.9	5	34
19	Dan Marino D. Marino	404	12/12/1988	MIA	vs	CLE	30	50	60.0	8.1	4	3	87.4	8.0	6.0	0	0
20	Dan Marino D. Marino	404	12/9/1984	MIA	@	IND	29	41	70.7	9.9	4	1	124.4	9.8	2.4	2	17
21	Dan Marino D. Marino	403	12/14/1986	MIA	@	RAM	29	46	63.0	8.8	5	1	118.3	10.9	2.2	1	4
22	Ryan Fitzpatrick R. Fitzpatrick	402	12/15/2013	TEN	vs	ARI	36	58	62.1	6.9	4	2	91.3	6.9	3.4	3	8
23	Drew Brees D. Brees	393	12/15/2013	NO	@	STL	39	56	69.6	7.0	1	2	80.4	1.8	3.6	4	22
24	Steve Young S. Young	393	12/8/1996	SF	vs	CAR	27	41	65.9	9.6	3	2	101.0	7.3	4.9	5	18
25	Dan Marino D. Marino	393	12/20/1987	MIA	vs	WAS	22	50	44.0	7.9	3	1	83.2	6.0	2.0	0	0

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Results may be incomplete. StatMuse has complete game-level data for passing yards going back to the 1950 season.

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AFC East	W	L	T	PCT
Patriots - y	14	3	0	.824
Bills - w	12	5	0	.706
Dolphins - e	7	10	0	.412
Jets - e	3	14	0	.176
AFC North	W	L	T	PCT
Steelers - y	10	7	0	.588
Ravens - e	8	9	0	.471
Bengals - e	6	11	0	.353
Browns - e	5	12	0	.294
AFC South	W	L	T	PCT
Jaguars - y	13	4	0	.765
Texans - w	12	5	0	.706
Colts - e	8	9	0	.471
Titans - e	3	14	0	.176
AFC West	W	L	T	PCT
Broncos - z*	14	3	0	.824
Chargers - w	11	6	0	.647
Chiefs - e	6	11	0	.353
Raiders - e	3	14	0	.176

NFC East	W	L	T	PCT
Eagles - y	11	6	0	.647
Cowboys - e	7	9	1	.441
Commanders - e	5	12	0	.294
Giants - e	4	13	0	.235
NFC North	W	L	T	PCT
Bears - y	11	6	0	.647
Packers - w	9	7	1	.559
Vikings - e	9	8	0	.529
Lions - e	9	8	0	.529
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Panthers - y	8	9	0	.471
Buccaneers - e	8	9	0	.471
Falcons - e	8	9	0	.471
Saints - e	6	11	0	.353
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Seahawks - z*	14	3	0	.824
Rams - w	12	5	0	.706
49ers - w	12	5	0	.706
Cardinals - e	3	14	0	.176