| TEAM | OPPONENT | WEEK/ROUND | DATE | TIME (ET) | SPREAD | OVER/UNDER | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | San Francisco 49ers | +353 | @ |  Los Angeles Rams | -459 | WK 5 | Thu, Oct 2, 2025 | 8:15 PM | +8.5 | 43.5 |
| 2 |  | Cleveland Browns | +168 | vs |  Minnesota Vikings | -204 | WK 5 | Sun, Oct 5, 2025 | 9:30 AM | +3.5 | 36.0 |
| 3 |  | Baltimore Ravens | +109 | vs |  Houston Texans | -130 | WK 5 | Sun, Oct 5, 2025 | 1:00 PM | +2.0 | 40.5 |
| 4 |  | New York Giants | +107 | @ |  New Orleans Saints | -127 | WK 5 | Sun, Oct 5, 2025 | 1:00 PM | +1.5 | 42.0 |
| 5 |  | Denver Broncos | +170 | @ |  Philadelphia Eagles | -206 | WK 5 | Sun, Oct 5, 2025 | 1:00 PM | +3.5 | 43.5 |
| 6 |  | New York Jets | +119 | vs |  Dallas Cowboys | -142 | WK 5 | Sun, Oct 5, 2025 | 1:00 PM | +2.5 | 47.5 |
| 7 |  | Las Vegas Raiders | +250 | @ |  Indianapolis Colts | -313 | WK 5 | Sun, Oct 5, 2025 | 1:00 PM | +6.5 | 48.0 |
| 8 |  | Carolina Panthers | -102 | vs |  Miami Dolphins | -118 | WK 5 | Sun, Oct 5, 2025 | 1:00 PM | +1.5 | 44.5 |
| 9 |  | Tennessee Titans | +326 | @ |  Arizona Cardinals | -426 | WK 5 | Sun, Oct 5, 2025 | 4:05 PM | +7.5 | 42.5 |
| 10 |  | Tampa Bay Buccaneers | +154 | @ |  Seattle Seahawks | -185 | WK 5 | Sun, Oct 5, 2025 | 4:05 PM | +3.5 | 44.5 |
| 11 |  | Cincinnati Bengals | +415 | vs |  Detroit Lions | -571 | WK 5 | Sun, Oct 5, 2025 | 4:25 PM | +10.5 | 49.5 |
| 12 |  | Washington Commanders | +130 | @ |  Los Angeles Chargers | -154 | WK 5 | Sun, Oct 5, 2025 | 4:25 PM | +2.5 | 48.0 |
| 13 |  | New England Patriots | +340 | @ |  Buffalo Bills | -439 | WK 5 | Sun, Oct 5, 2025 | 8:20 PM | +8.0 | 49.5 |
| 14 |  | Jacksonville Jaguars | +153 | vs |  Kansas City Chiefs | -184 | WK 5 | Mon, Oct 6, 2025 | 8:15 PM | +3.5 | 46.5 |
| 15 | | New York Giants | +323 | vs | Philadelphia Eagles | -408 | WK 6 | Thu, Oct 9, 2025 | 8:15 PM | +7.5 | 42.5 |
| 16 | | New York Jets | +227 | vs |  Denver Broncos | -279 | WK 6 | Sun, Oct 12, 2025 | 9:30 AM | +6.5 | 43.0 |
| 17 |  | Arizona Cardinals | +164 | @ | Indianapolis Colts | -197 | WK 6 | Sun, Oct 12, 2025 | 1:00 PM | +3.5 | 47.5 |
| 18 | | Baltimore Ravens | +196 | vs | Los Angeles Rams | -238 | WK 6 | Sun, Oct 12, 2025 | 1:00 PM | +5.5 | 44.5 |
| 19 | | Cleveland Browns | +217 | @ |  Pittsburgh Steelers | -263 | WK 6 | Sun, Oct 12, 2025 | 1:00 PM | +6.0 | 38.5 |
| 20 |  | Seattle Seahawks | -103 | @ |  Jacksonville Jaguars | -117 | WK 6 | Sun, Oct 12, 2025 | 1:00 PM | +1.5 | 45.0 |
| 21 |  | Miami Dolphins | +203 | vs | Los Angeles Chargers | -248 | WK 6 | Sun, Oct 12, 2025 | 1:00 PM | +5.5 | 45.5 |
| 22 | | Carolina Panthers | +158 | vs | Dallas Cowboys | -189 | WK 6 | Sun, Oct 12, 2025 | 1:00 PM | +3.5 | 47.5 |
| 23 |  | New Orleans Saints | +159 | vs |  New England Patriots | -189 | WK 6 | Sun, Oct 12, 2025 | 1:00 PM | +3.5 | 44.5 |
| 24 | | Tennessee Titans | +248 | @ |  Las Vegas Raiders | -309 | WK 6 | Sun, Oct 12, 2025 | 4:05 PM | +6.5 | 41.5 |
| 25 | | San Francisco 49ers | +107 | @ |  Tampa Bay Buccaneers | -127 | WK 6 | Sun, Oct 12, 2025 | 4:25 PM | +2.0 | 47.0 |
Betting lines shown represent consensus, closing odds.
More 49ers Stats
Team Rankings
PPG
20.0
23rd
OPP PPG
18.8
7th
RUSH YDS/G
88.0
28th
PASS YDS/G
287.3
2nd
NYG 
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
| Eagles | 4 | 0 | 0 | 1.000 |
 Commanders | 2 | 2 | 0 | .500 |
| NFC North | W | L | T | PCT |
| Lions | 3 | 1 | 0 | .750 |
 Packers | 2 | 1 | 1 | .625 |
| NFC South | W | L | T | PCT |
| Buccaneers | 3 | 1 | 0 | .750 |
 Falcons | 2 | 2 | 0 | .500 |
| NFC West | W | L | T | PCT |
 49ers | 3 | 1 | 0 | .750 |
| Seahawks | 3 | 1 | 0 | .750 |
Bengals 
NYJ 
CLE 
BAL 
