12 players are tied for the most interceptions in a game, with 4 interceptions. The first three are DeAngelo Hall on October 24, 2010, Deltha O'Neal on October 7, 2001 and Kwamie Lassiter on December 27, 1998.

Interpreted as:

What are the most defensive int by a player in a regular-season game by?

	NAME	INT	DATE	TM		OPP	TKL	AST	COMB	SCK	SCKY	INT YDS	INT TD	FF	FR	FR TD
1	DeAngelo Hall D. Hall	4	10/24/2010	WAS	@	CHI	7	0	7	0.0	0	92	1	0	0	0
2	Deltha O'Neal D. O'Neal	4	10/7/2001	DEN	vs	KC	3	0	3	0.0	0	69	0	0	0	0
3	Kwamie Lassiter K. Lassiter	4	12/27/1998	ARI	vs	SD				0.0		36	0			0
4	Deron Cherry D. Cherry	4	9/29/1985	KC	vs	SEA				0.0		24	0			0
5	Willie Buchanon W. Buchanon	4	9/24/1978	GB	@	SD						77	1			0
6	Dick Anderson D. Anderson	4	12/3/1973	MIA	vs	PIT						121	2			0
7	Willie Brown W. Brown	4	11/15/1964	DEN	vs	NYJ						91	0			0
8	Bobby Hunt B. Hunt	4	10/4/1964	KC	vs	HOU						108	1			0
9	Bobby Ply B. Ply	4	12/16/1962	DLT	vs	SD						108	0			0
10	Jerry Norton J. Norton	4	11/26/1961	STL	@	PIT						110	2			0
11	Dave Baker D. Baker	4	12/4/1960	SF	@	LA						49	0			0
12	Jerry Norton J. Norton	4	11/20/1960	STL	@	WAS						20	0			0
13	Goose Gonsoulin G. Gonsoulin	4	9/18/1960	DEN	@	BUF						28	0			0
14	Jordan Whitehead J. Whitehead	3	9/11/2023	NYJ	vs	BUF	1	1	2	0.0	0	0	0	0	0	0
15	Andrew Adams A. Adams	3	12/2/2018	TB	vs	CAR	1	0	1	0.0	0	21	0	0	0	0
16	Kevin Byard III K. Byard III	3	10/22/2017	TEN	@	CLE	2	2	4	0.0	0	60	0	0	0	0
17	Kurt Coleman K. Coleman	3	10/16/2011	PHI	@	WAS	5	2	7	0.0	0	25	0	0	0	0
18	Glover Quin G. Quin	3	11/28/2010	HOU	vs	TEN	3	1	4	0.0	0	12	0	0	0	0
19	Leigh Bodden L. Bodden	3	11/22/2009	NE	vs	NYJ	3	0	3	0.0	0	60	1	0	0	0
20	Aqib Talib A. Talib	3	10/4/2009	TB	@	WAS	4	0	4	0.0	0	61	0	0	0	0
21	Leon Hall L. Hall	3	12/21/2008	CIN	@	CLE	1	1	2	0.0	0	87	1	0	0	0
22	Marcus Trufant M. Trufant	3	12/9/2007	SEA	vs	ARI	4	2	6	0.0	0	96	1	0	0	0
23	Lofa Tatupu L. Tatupu	3	12/2/2007	SEA	@	PHI	11	0	11	0.0	0	100	0	0	0	0
24	Antrel Rolle A. Rolle	3	11/18/2007	ARI	@	CIN	3	1	4	0.0	0	127	2	0	0	0
25	Antonio Cromartie A. Cromartie	3	11/11/2007	SD	vs	IND	6	0	6	0.0	0	27	0	0	0	0

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Results may be incomplete. StatMuse has complete game-level data for interceptions going back to the 1960 season.

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12 players are tied for the most interceptions in a game, with 4 interceptions. The first three are DeAngelo Hall on October 24, 2010, Deltha O'Neal on October 7, 2001 and Kwamie Lassiter on December 27, 1998.

Interpreted as:

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