12 players are tied for the most interceptions in a game, with 4 interceptions. The first three are DeAngelo Hall on October 24, 2010, Deltha O'Neal on October 7, 2001 and Kwamie Lassiter on December 27, 1998.

what was the games the most interceptions in nfl
Interpreted as:
What was the regular-season games the most defensive interceptions by a player in NFL?
Results may be incomplete. StatMuse has complete game-level data for interceptions going back to the 1960 season.

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