12 players are tied for the most interceptions in a game, with 4 interceptions. The first three are DeAngelo Hall on October 24, 2010, Deltha O'Neal on October 7, 2001 and Kwamie Lassiter on December 27, 1998.

which nfl player has the most interceptions in a game
Interpreted as:
Which NFL player has the most defensive interceptions in a regular-season game?

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