which nfl player most rushing yard in a game to lost

O.J. Simpson has the most rushing yards in a loss, with 273 yards against the Lions on November 25, 1976.

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All-time
Regular season

	NAME	RUSH YDS	DATE	TM		OPP	ATT	YPC	RUSH TD	REC YDS	REC	TRG	AVG	REC TD
1	O.J. Simpson	273	11/25/1976	BUF	@	DET	29	9.4	2	0	0			0
2	Ricky Williams R. Williams	228	12/1/2002	MIA	@	BUF	27	8.4	2	7	4	6	1.8	0
3	Jamaal Charles J. Charles	226	12/23/2012	KC	vs	IND	22	10.3	1	4	1	3	4.0	0
4	Knowshon Moreno K. Moreno	224	11/24/2013	DEN	@	NE	37	6.1	1	6	1	1	6.0	0
5	Gerald Riggs G. Riggs	221	9/17/1989	WAS	vs	PHI	29	7.6	1	0	0			0
6	John Fuqua J. Fuqua	218	12/20/1970	PIT	@	PHI	20	10.9	2	38	3		12.7	0
7	Adrian Peterson A. Peterson	210	12/2/2012	MIN	@	GB	21	10.0	1	10	1	2	10.0	0
8	Thomas Jones T. Jones	210	10/18/2009	NYJ	vs	BUF	22	9.5	1	17	2	2	8.5	0
9	Rueben Mayes R. Mayes	203	12/7/1986	NO	vs	MIA	28	7.3	2	22	2		11.0	0
10	O.J. Simpson	203	12/5/1976	BUF	@	MIA	24	8.5	1	12	2		6.0	0
11	Chris Johnson C. Johnson	197	9/20/2009	TEN	vs	HOU	16	12.3	2	87	9	11	9.7	1
12	Priest Holmes P. Holmes	197	11/24/2002	KC	@	SEA	23	8.6	2	110	7	7	15.7	1
13	Gerald Riggs G. Riggs	197	12/8/1985	ATL	@	KC	26	7.6	1	22	3		7.3	0
14	Wilbert Montgomery W. Montgomery	197	11/4/1979	PHI	vs	CLE	30	6.6	1	40	3		13.3	0
15	O.J. Simpson	197	11/17/1975	BUF	@	CIN	17	11.6	2	21	2		10.5	0
16	Robert Edwards R. Edwards	196	12/13/1998	NE	@	STL	24	8.2	0	0	0			0
17	Delvin Williams D. Williams	194	10/31/1976	SF	@	STL	34	5.7	3	8	1		8.0	0
18	Carlos Hyde C. Hyde	193	12/11/2016	SF	vs	NYJ	17	11.4	0	7	1	1	7.0	1
19	Ottis Anderson O. Anderson	193	9/2/1979	STL	vs	DAL	21	9.2	1	0	0			0
20	Ahman Green A. Green	192	11/10/2003	GB	vs	PHI	29	6.6	1	32	3	4	10.7	1
21	Marshall Faulk M. Faulk	192	11/29/1998	IND	@	BAL	17	11.3	1	75	7		10.7	1
22	Erric Pegram E. Pegram	192	9/19/1993	ATL	@	SF	27	7.1	0	5	1		5.0	0
23	Eric Dickerson E. Dickerson	192	9/25/1983	RAM	@	NYJ	28	6.9	2	45	5		9.0	0
24	Johnny Olszewski J. Olszewski	190	11/15/1959	WAS	vs	CLE	18	10.6	1	0	1		0.0	0
25	O.J. Simpson	189	10/29/1972	BUF	vs	PIT	22	8.6	1	7	3		2.3	0

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Results may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.

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RUSH YDS/G

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TEAM	W	L	PCT
Bills	3	0	1.000
Patriots	1	2	.333
Jets	1	2	.333
Dolphins	0	3	.000

Schedule

DATE	MATCHUP			TIME (ET)
Sun 10/4	NE	@	BUF	1:00 PM
Mon 10/12	BUF	@	LAR	8:15 PM
Sun 10/18	BUF	@	LV	4:25 PM
Sun 11/1	BAL	@	BUF	1:00 PM
Mon 11/9	BUF	@	MIN	8:15 PM

Last Game

Chargers

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3 - 0

Sun 27 Sep 2026

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Pass Yards Leaders

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NFC East	W	L	T	PCT
Eagles	2	1	0	.667
Giants	2	1	0	.667
Cowboys	1	2	0	.333
Commanders	1	2	0	.333
NFC North	W	L	T	PCT
Vikings	3	0	0	1.000
Lions	2	1	0	.667
Bears	2	1	0	.667
Packers	1	2	0	.333
NFC South	W	L	T	PCT
Panthers	1	2	0	.333
Saints	1	2	0	.333
Falcons	1	2	0	.333
Buccaneers	0	3	0	.000
NFC West	W	L	T	PCT
49ers	3	0	0	1.000
Seahawks	2	1	0	.667
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Cardinals	1	2	0	.333

AFC East	W	L	T	PCT
Bills	3	0	0	1.000
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AFC North	W	L	T	PCT
Browns	3	1	0	.750
Ravens	2	1	0	.667
Bengals	2	1	0	.667
Steelers	2	2	0	.500
AFC South	W	L	T	PCT
Jaguars	2	1	0	.667
Colts	1	2	0	.333
Titans	0	3	0	.000
Texans	0	3	0	.000
AFC West	W	L	T	PCT
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DATE	MATCHUP			SCORE
Wed 9/9	NE	@	SEA	10-13
Thu 9/10	SF	@	LAR	27-7
Sun 9/13	CHI	@	CAR	59-37
Sun 9/13	BAL	@	IND	41-23
Sun 9/13	ATL	@	PIT	13-20

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DATE	MATCHUP			TIME (ET)
Sun 10/4	IND	@	WAS	9:30 AM
Sun 10/4	ARI	@	NYG	1:00 PM
Sun 10/4	NE	@	BUF	1:00 PM
Sun 10/4	NYJ	@	CHI	1:00 PM
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O.J. Simpson has the most rushing yards in a loss, with 273 yards against the Lions on November 25, 1976.

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