| TEAM | OPPONENT | WEEK/ROUND | DATE | TIME (ET) | SPREAD | OVER/UNDER | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Seattle Seahawks | -204 | vs | +170 | WK 1 | Wed, Sep 9, 2026 | 8:20 PM | -3.5 | 44.5 | |
| 2 |  | San Francisco 49ers | +162 | @ | -193 | WK 1 | Thu, Sep 10, 2026 | 8:35 PM | +3.5 | 48.5 | |
| 3 | | Seattle Seahawks | -490 | @ | +385 | WK 2 | Sun, Sep 20, 2026 | 4:25 PM | -10.0 | 44.5 | |
| 4 | | San Francisco 49ers | -562 | vs | +413 | WK 2 | Sun, Sep 20, 2026 | 4:25 PM | -10.5 | 46.5 | |
| 5 | | Seattle Seahawks | -196 | @ | +155 | WK 3 | Sun, Sep 27, 2026 | 1:00 PM | -3.5 | 46.5 | |
| 6 | | San Francisco 49ers | -585 | vs | +413 | WK 3 | Sun, Sep 27, 2026 | 4:05 PM | -11.5 | 46.5 | |
| 7 | | Seattle Seahawks | -175 | vs | +141 | WK 4 | Sun, Oct 4, 2026 | 4:25 PM | -3.0 | 45.5 | |
| 8 | | San Francisco 49ers | -151 | vs | +123 | WK 4 | Sun, Oct 4, 2026 | 4:25 PM | -2.5 | 46.5 | |
| 9 | | Seattle Seahawks | -208 | vs | +165 | WK 5 | Sun, Oct 11, 2026 | 4:25 PM | -3.5 | 48.5 | |
| 10 | | Seattle Seahawks | -128 | @ | +102 | WK 6 | Thu, Oct 15, 2026 | 8:15 PM | -2.5 | 43.5 | |
| 11 | | San Francisco 49ers | -204 | vs | +170 | WK 11 | Sun, Nov 22, 2026 | 8:20 PM | -4.5 | 46.5 | |
| 12 | | Seattle Seahawks | -114 | vs | -104 | WK 16 | Fri, Dec 25, 2026 | 8:15 PM | -1.5 | 46.5 |
Betting lines shown represent consensus, closing odds.
More NFL News
Deebo Samuel returns to the 49ers on a 1-year deal worth up to $7M, AP source says
Panthers rookie WR Chris Brazzell to have season-ending surgery on his knee
Raiders hope Linderbaum's addition and Miller's return to health boost ailing offensive line
Sam Darnold uninterested in narratives about him, but ready to help Seahawks defend Super Bowl crown
Packers' Nixon says hamstring tightness caused him to miss first practice
Saints receiver Chris Olave agrees to a 4-year extension worth up to $132 million
More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |