Drew Brees is the oldest quarterback in a game with 500+ passing yards. He was 36 years and 290 days old versus the Giants on November 1, 2015.

who is the oldest qb to throw 500 yards in a game
Interpreted as:
Who is the oldest qb to throw 500 or more yards in a regular-season game?
11/1/2015Brees10/28/1962Tittle12/10/2017Roethlisberger11/10/1996Esiason9/12/2011Brady12/16/1990Moon10/18/2015Rivers10/6/2013Romo10/26/2014Roethlisberger9/16/2012Manning11/18/2012Schaub10/2/2016Ryan10/13/1985Simms11/5/2000Grbac12/26/1982Ferragamo11/19/2006Brees12/20/2009Roethlisberger10/4/2020Prescott10/23/1988Marino10/30/2016Carr9/28/1951Van Brocklin9/29/2019Goff1/1/2012Stafford36-29036-00435-28335-20734-04034-02833-31433-16832-23831-25731-14631-13830-34430-08428-24627-30827-29327-06727-03825-21625-19724-35023-328
NAMEDATETMOPPAGEYDSCMPATTPCTAVGTDTD%INTINT%SCKSCKYRATE
Drew BreesDrew Brees11/1/2015NONOvsNYGNYG36-290505395078.010.1714.024.000131.7
Y.A. TittleY.A. Tittle10/28/1962NYGNYGvsWASWAS36-004505273969.212.9717.900.0151.4
Ben RoethlisbergerBen Roethlisberger12/10/2017PITPITvsBALBAL35-283506446666.77.723.000.032099.7
Boomer EsiasonBoomer Esiason11/10/1996ARIARI@WASWAS35-207522355959.38.835.146.821577.1
Tom BradyTom Brady9/12/2011NENE@MIAMIA34-040517324866.710.848.312.111121.6
Warren MoonWarren Moon12/16/1990HOUHOU@KCKC34-028527274560.011.736.700.0322123.1
Philip RiversPhilip Rivers10/18/2015SDSD@GBGB33-314503436566.27.723.100.031599.7
Tony RomoTony Romo10/6/2013DALDALvsDENDEN33-168506253669.414.1513.912.8436140.0
Ben RoethlisbergerBen Roethlisberger10/26/2014PITPITvsINDIND32-238522404981.610.7612.200.000150.6
Eli ManningEli Manning9/16/2012NYGNYGvsTBTB31-257510315160.810.035.935.90089.5
Matt SchaubMatt Schaub11/18/2012HOUHOUvsJAXJAX31-146527435578.29.659.123.6223121.7
Matt RyanMatt Ryan10/2/2016ATLATLvsCARCAR31-138503283775.713.6410.812.7322142.0
Phil SimmsPhil Simms10/13/1985NYGNYG@CINCIN30-344513406264.58.311.623.277082.3
Elvis GrbacElvis Grbac11/5/2000KCKC@OAKOAK30-084504395373.69.523.823.843099.9
Vince FerragamoVince Ferragamo12/26/1982RAMRAMvsCHICHI28-246509304665.211.136.524.313106.2
Drew BreesDrew Brees11/19/2006NONOvsCINCIN27-308510375271.29.823.835.82691.0
Ben RoethlisbergerBen Roethlisberger12/20/2009PITPITvsGBGB27-293503294663.010.936.500.0531121.9
Dak PrescottDak Prescott10/4/2020DALDALvsCLECLE27-067502415870.78.746.911.7321112.9
Dan MarinoDan Marino10/23/1988MIAMIAvsNYJNYJ27-038521356058.38.735.058.30068.8
Derek CarrDerek Carr10/30/2016OAKOAK@TBTB25-216513405967.88.746.800.0215117.4
Norm Van BrocklinNorm Van Brocklin9/28/1951LALAvsNYYNYY25-197554274165.913.5512.224.9128.3
Jared GoffJared Goff9/29/2019LARLARvsTBTB24-350517456866.27.622.934.422780.3
Matthew StaffordMatthew Stafford1/1/2012DETDET@GBGB23-328520365961.08.858.523.4218103.8
Results may be incomplete. StatMuse has complete game-level data for passing yards going back to the 1950 season.

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