| TEAM | OPPONENT | WEEK/ROUND | DATE | TIME (ET) | SPREAD | OVER/UNDER | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Jacksonville Jaguars | -392 | vs | +308 | WK 1 | Sun, Sep 13, 2026 | 1:00 PM | -7.5 | 40.5 | |
| 2 |  | Buffalo Bills | -113 | @ | -106 | WK 1 | Sun, Sep 13, 2026 | 1:00 PM | -1.5 | 44.5 | |
| 3 | | Buffalo Bills | -161 | vs | +136 | WK 2 | Thu, Sep 17, 2026 | 8:15 PM | -3.0 | 52.5 | |
| 4 | | Jacksonville Jaguars | +127 | @ | -155 | WK 2 | Sun, Sep 20, 2026 | 4:05 PM | +2.5 | 43.5 | |
| 5 | | Jacksonville Jaguars | -124 | vs | -101 | WK 3 | Sun, Sep 27, 2026 | 1:00 PM | -1.5 | 45.5 | |
| 6 | | Buffalo Bills | -170 | vs | +138 | WK 3 | Sun, Sep 27, 2026 | 1:00 PM | -3.0 | 48.5 | |
| 7 | | Buffalo Bills | -181 | vs | +150 | WK 4 | Sun, Oct 4, 2026 | 1:00 PM | -3.0 | 49.5 | |
| 8 | | Jacksonville Jaguars | +122 | @ | -150 | WK 4 | Sun, Oct 4, 2026 | 1:00 PM | +2.5 | 51.5 | |
| 9 | | Jacksonville Jaguars | +106 | vs | -125 | WK 5 | Sun, Oct 11, 2026 | 9:30 AM | +1.5 | 44.5 | |
| 10 | | Buffalo Bills | +160 | @ | -193 | WK 5 | Mon, Oct 12, 2026 | 8:15 PM | +3.0 | 53.5 | |
| 11 | | Jacksonville Jaguars | -108 | vs | -111 | WK 6 | Sun, Oct 18, 2026 | 9:30 AM | -1.5 | 41.5 | |
| 12 | | Buffalo Bills | -158 | vs | +134 | WK 12 | Thu, Nov 26, 2026 | 8:20 PM | -2.5 | 50.5 | |
| 13 | | Buffalo Bills | -127 | @ | +107 | WK 16 | Fri, Dec 25, 2026 | 4:30 PM | -1.5 | 46.5 |
Betting lines shown represent consensus, closing odds.
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More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |