The San Francisco 49ers have a 2-4 record in the regular-season and playoffs versus the Bills on the road all-time.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/24/1972 | 0-1 |  SF | @ |  BUF | L 20-27 | .000 | 2 | 10 | 202 | 233 | ||
| 2 | | 49ers | 12/11/1983 | 1-0 | SF | @ | BUF | W 23-10 | 1.000 | 2 | 19 | 310 | 303 | ||
| 3 | | 49ers | 10/4/1998 | 0-1 | SF | @ | BUF | L 21-26 | .000 | 3 | 23 | 377 | 352 | 46.2 | |
| 4 | | 49ers | 11/30/2008 | 1-0 | SF | @ | BUF | W 10-3 | 1.000 | 1 | 12 | 195 | 350 | 46.7 | |
| 5 | | 49ers | 10/16/2016 | 0-1 | SF | @ | BUF | L 16-45 | .000 | 1 | 16 | 300 | 492 | 23.1 | 0.0 |
| 6 | | 49ers | 12/1/2024 | 0-1 | SF | @ | BUF | L 10-35 | .000 | 1 | 15 | 239 | 372 | 30.0 | 100.0 |
| Average | .333 | 1.7 | 15.8 | 270.5 | 350.3 | 16.7 | |||||||||
| Total | 2-4 | .333 | 10 | 95 | 1,623 | 2,102 | 33.3 |
More 49ers Stats
Team Rankings
PPG
20.8
24th
OPP PPG
21.3
14th
RUSH YDS/G
82.2
30th
PASS YDS/G
306.3
1st
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Broncos | NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 4 | 2 | 0 | .667 |
 Commanders | 3 | 2 | 0 | .600 |
| NFC North | W | L | T | PCT |
 Packers | 3 | 1 | 1 | .700 |
 Lions | 4 | 2 | 0 | .667 |
| NFC South | W | L | T | PCT |
 Buccaneers | 5 | 1 | 0 | .833 |
 Panthers | 3 | 3 | 0 | .500 |
| NFC West | W | L | T | PCT |
| 49ers | 4 | 2 | 0 | .667 |
 Seahawks | 4 | 2 | 0 | .667 |
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