The San Francisco 49ers have a record of 5-10 against the spread against the AFC since November 1, 2022.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 11/13/2022 | 0-1 |  SF | -361 | vs |  LAC | +284 | W 22-16 | -8 | -2 (N) | 45.5 | -7.5 (U) | 2 | 22 | 387 | 238 | 52.9 | 100.0 |
| 2 | | 49ers | 12/4/2022 | 1-0 | SF | -233 | vs |  MIA | +191 | W 33-17 | -5 | +11 (Y) | 46 | +4 (O) | 3 | 24 | 351 | 308 | 42.1 | 50.0 |
| 3 | | 49ers | 1/1/2023 | 0-1 | SF | -472 | @ |  LV | +359 | W 37-34 | -10 | -7 (N) | 41 | +30 (O) | 4 | 27 | 454 | 500 | 50.0 | |
| 4 | | 49ers | 9/10/2023 | 1-0 | SF | -121 | @ |  PIT | +102 | W 30-7 | -1.5 | +21.5 (Y) | 41.5 | -4.5 (U) | 3 | 22 | 391 | 239 | 46.2 | 100.0 |
| 5 | | 49ers | 10/15/2023 | 0-1 | SF | -507 | @ |  CLE | +379 | L 17-19 | -9.5 | -11.5 (N) | 36 | 0 (P) | 2 | 15 | 215 | 334 | 25.0 | |
| 6 | | 49ers | 10/29/2023 | 0-1 | SF | -211 | vs |  CIN | +173 | L 17-31 | -4 | -18 (N) | 44 | +4 (O) | 2 | 24 | 460 | 400 | 55.6 | |
| 7 | | 49ers | 11/12/2023 | 1-0 | SF | -172 | @ |  JAX | +144 | W 34-3 | -3 | +28 (Y) | 44.5 | -7.5 (U) | 4 | 20 | 437 | 221 | 33.3 | 50.0 |
| 8 | | 49ers | 12/25/2023 | 0-1 | SF | -296 | vs |  BAL | +238 | L 19-33 | -6.5 | -20.5 (N) | 47 | +5 (O) | 2 | 21 | 429 | 343 | 42.9 | 33.3 |
| 9 | | 49ers | 9/9/2024 | 1-0 | SF | -195 | vs |  NYJ | +163 | W 32-19 | -3.5 | +9.5 (Y) | 43 | +8 (O) | 2 | 24 | 401 | 266 | 46.2 | |
| 10 | | 49ers | 9/29/2024 | 1-0 | SF | -585 | vs |  NE | +432 | W 30-13 | -10.5 | +6.5 (Y) | 42.5 | +0.5 (O) | 3 | 19 | 431 | 216 | 53.8 | |
| 11 | | 49ers | 10/20/2024 | 0-1 | SF | -143 | vs |  KC | +121 | L 18-28 | -2.5 | -12.5 (N) | 48 | -2 (U) | 2 | 19 | 310 | 329 | 18.2 | 100.0 |
| 12 | | 49ers | 12/1/2024 | 0-1 | SF | +265 | @ |  BUF | -330 | L 10-35 | +6.5 | -18.5 (N) | 45.5 | -0.5 (U) | 1 | 15 | 239 | 372 | 30.0 | 100.0 |
| 13 | | 49ers | 12/22/2024 | 0-1 | SF | -127 | @ | MIA | +107 | L 17-29 | -2 | -14 (N) | 44.5 | +1.5 (O) | 2 | 20 | 374 | 381 | 38.5 | 0.0 |
| 14 | | 49ers | 9/28/2025 | 0-1 | SF | -178 | vs | JAX | +144 | L 21-26 | -3.5 | -8.5 (N) | 45.5 | +1.5 (O) | 2 | 22 | 389 | 325 | 61.5 | 0.0 |
| 15 | | 49ers | 10/26/2025 | 0-1 | SF | +135 | @ |  HOU | -159 | L 15-26 | +3 | -8 (N) | 42 | -1 (U) | 2 | 12 | 223 | 475 | 33.3 | 0.0 |
| Average | 2.2 | 2.4 | 20.4 | 366.1 | 329.8 | 42.5 | 5.0 | |||||||||||||
| Total | 5-10 | 36 | 306 | 5,491 | 4,947 | 42.5 | 50.0 |
StatMuse has team, game-level data for spread records going back to the 1979 season.
More 49ers Stats
Team Rankings
PPG
20.0
26th
OPP PPG
20.5
8th
RUSH YDS/G
89.4
30th
PASS YDS/G
272.9
2nd
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