The San Francisco 49ers have a 6-5 record against the spread against the AFC at home since November 1, 2022.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 11/13/2022 | 0-1 | -361 | vs | +284 | W 22-16 | -8 | -2 (N) | 45.5 | -7.5 (U) | 2 | 22 | 387 | 238 | 52.9 | 100.0 | ||
| 2 | | 49ers | 12/4/2022 | 1-0 | -233 | vs | +191 | W 33-17 | -5 | +11 (Y) | 46 | +4 (O) | 3 | 24 | 351 | 308 | 42.1 | 50.0 | ||
| 3 | | 49ers | 10/29/2023 | 0-1 | -211 | vs | +173 | L 17-31 | -4 | -18 (N) | 44 | +4 (O) | 2 | 24 | 460 | 400 | 55.6 | |||
| 4 | | 49ers | 12/25/2023 | 0-1 | -296 | vs | +238 | L 19-33 | -6.5 | -20.5 (N) | 47 | +5 (O) | 2 | 21 | 429 | 343 | 42.9 | 33.3 | ||
| 5 | | 49ers | 9/9/2024 | 1-0 | -195 | vs | +163 | W 32-19 | -3.5 | +9.5 (Y) | 43 | +8 (O) | 2 | 24 | 401 | 266 | 46.2 | |||
| 6 | | 49ers | 9/29/2024 | 1-0 | -585 | vs | +432 | W 30-13 | -10.5 | +6.5 (Y) | 42.5 | +0.5 (O) | 3 | 19 | 431 | 216 | 53.8 | |||
| 7 | | 49ers | 10/20/2024 | 0-1 | -143 | vs | +121 | L 18-28 | -2.5 | -12.5 (N) | 48 | -2 (U) | 2 | 19 | 310 | 329 | 18.2 | 100.0 | ||
| 8 | | 49ers | 9/28/2025 | 0-1 | -178 | vs | +144 | L 21-26 | -3.5 | -8.5 (N) | 45.5 | +1.5 (O) | 2 | 22 | 389 | 325 | 61.5 | 0.0 | ||
| 9 | | 49ers | 12/14/2025 | 1-0 | -952 | vs | +633 | W 37-24 | -12.5 | +0.5 (Y) | 44.5 | +16.5 (O) | 4 | 28 | 430 | 306 | 60.0 | 100.0 | ||
| 10 | | 49ers | 9/20/2026 | 1-0 | -980 | vs | +610 | W 35-13 | -13.5 | +8.5 (Y) | 45.5 | +2.5 (O) | 5 | 23 | 382 | 284 | 71.4 | |||
| 11 | | 49ers | 10/4/2026 | 1-0 | -175 | vs | +149 | W 24-14 | -3 | +7 (Y) | 48.5 | -10.5 (U) | 3 | 20 | 358 | 296 | 46.2 | 50.0 | ||
| Average | 5.0 | 2.7 | 22.4 | 393.5 | 301.0 | 49.3 | 0.1 | |||||||||||||
| Total | 6-5 | 30 | 246 | 4,328 | 3,311 | 49.3 | 54.5 |
SF
LAC
MIA
CIN
BAL
NYJ
NE
KC
JAX
TEN
DENStatMuse has team, game-level data for spread records going back to the 1979 season.
More NFL News
Jaguars CB Jarrian Jones relives Saquon Barkley's backward hurdle two years later
Bo Nix isn't taking any advice from TV analysts about how to fix the Broncos' offense
49ers DE Mykel Williams excited to get back on the field for 1st time since knee surgery
A tough first loss for the Raiders, now a quick turnaround at New England
Bengals' receiver depth tested as Ja'Marr Chase and Tee Higgins deal with injuries
Packers tight end Tucker Kraft struggling with drops as he comes back from torn ACL
More 49ers Stats
Team Leaders 
PASS
1,007
Purdy
RUSH
218
McCaffrey
REC
244
Kittle
Team Rankings
PPG
30.5
2nd
OPP PPG
16.0
3rd
RUSH YDS/G
137.3
6th
PASS YDS/G
251.8
13th
Seahawks
Rams
Cardinals
WAS
ATL
LV
DAL
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
2 | 2 | 0 | .500 | |
1 | 3 | 0 | .250 | |
| NFC North | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
2 | 2 | 0 | .500 | |
| NFC South | W | L | T | PCT |
2 | 2 | 0 | .500 | |
2 | 2 | 0 | .500 | |
1 | 3 | 0 | .250 | |
0 | 4 | 0 | .000 | |
| NFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
1 | 3 | 0 | .250 |
Giants
Eagles
Vikings
Bears
Lions
Packers
Panthers
Saints
Buccaneers| AFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
1 | 3 | 0 | .250 | |
0 | 4 | 0 | .000 | |
| AFC North | W | L | T | PCT |
3 | 1 | 0 | .750 | |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
2 | 2 | 0 | .500 | |
| AFC South | W | L | T | PCT |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
0 | 4 | 0 | .000 | |
0 | 4 | 0 | .000 | |
| AFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
0 | 4 | 0 | .000 |
Bills
Browns
Steelers
Colts
Texans