The Buffalo Bills have a record of 12-5 in the month of September against the NFC on the road all-time.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 9/21/1980 | 1-0 | @ | W 35-26 | 1.000 | 5 | 26 | 410 | 316 | ||||
| 2 | | Bills | 9/9/1984 | 0-1 | @ | L 7-37 | .000 | 1 | 9 | 171 | 486 | ||||
| 3 | | Bills | 9/22/1991 | 1-0 | @ | W 17-10 | 1.000 | 2 | 19 | 421 | 303 | 36.4 | 0.0 | ||
| 4 | | Bills | 9/13/1992 | 1-0 | @ | W 34-31 | 1.000 | 4 | 25 | 488 | 598 | 50.0 | 100.0 | ||
| 5 | | Bills | 9/12/1993 | 1-0 | @ | W 13-10 | 1.000 | 1 | 16 | 229 | 393 | 33.3 | |||
| 6 | | Bills | 9/1/1996 | 1-0 | @ | W 23-20 | 1.000 | 2 | 25 | 410 | 231 | 40.0 | |||
| 7 | | Bills | 9/15/2002 | 1-0 | @ | W 45-39 | 1.000 | 5 | 26 | 468 | 449 | 33.3 | |||
| 8 | | Bills | 9/18/2005 | 0-1 | @ | L 3-19 | .000 | 0 | 8 | 147 | 318 | 28.6 | 0.0 | ||
| 9 | | Bills | 9/28/2008 | 1-0 | @ | W 31-14 | 1.000 | 3 | 14 | 277 | 380 | 23.1 | |||
| 10 | | Bills | 9/19/2010 | 0-1 | @ | L 7-34 | .000 | 1 | 14 | 186 | 346 | 33.3 | 0.0 | ||
| 11 | | Bills | 9/7/2014 | 1-0 | @ | W 23-20 | 1.000 | 2 | 15 | 360 | 427 | 33.3 | |||
| 12 | | Bills | 9/17/2017 | 0-1 | @ | L 3-9 | .000 | 0 | 10 | 176 | 255 | 30.8 | 0.0 | ||
| 13 | | Bills | 9/23/2018 | 1-0 | @ | W 27-6 | 1.000 | 3 | 16 | 292 | 292 | 30.8 | 100.0 | ||
| 14 | | Bills | 9/30/2018 | 0-1 | @ | L 0-22 | .000 | 0 | 11 | 145 | 423 | 18.8 | |||
| 15 | | Bills | 9/15/2019 | 1-0 | @ | W 28-14 | 1.000 | 4 | 24 | 388 | 370 | 38.5 | |||
| 16 | | Bills | 9/8/2022 | 1-0 | @ | W 31-10 | 1.000 | 4 | 23 | 413 | 243 | 90.0 | |||
| 17 | | Bills | 9/24/2023 | 1-0 | @ | W 37-3 | 1.000 | 4 | 20 | 386 | 230 | 60.0 | 0.0 | ||
| Average | .706 | 2.4 | 17.7 | 315.7 | 356.5 | ||||||||||
| Total | 12-5 | .706 | 41 | 301 | 5,367 | 6,060 |
STL
STL
CHIMore Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
