The Buffalo Bills have a record of 12-15 against the spread in the regular season and playoffs against the AFC on the road since July 31, 2022.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 9/25/2022 | 0-1 | -206 | @ | +171 | L 19-21 | -4.5 | -6.5 (N) | 54.5 | -14.5 (U) | 2 | 31 | 497 | 212 | 61.1 | 66.7 | ||
| 2 | | Bills | 10/2/2022 | 0-1 | -173 | @ | +144 | W 23-20 | -3.5 | -0.5 (N) | 50.5 | -7.5 (U) | 2 | 22 | 326 | 296 | 36.4 | 100.0 | ||
| 3 | | Bills | 10/16/2022 | 1-0 | -148 | @ | +124 | W 24-20 | -2.5 | +1.5 (Y) | 54 | -10 (U) | 3 | 26 | 443 | 387 | 36.4 | 33.3 | ||
| 4 | | Bills | 11/6/2022 | 0-1 | -562 | @ | +410 | L 17-20 | -10.5 | -13.5 (N) | 46 | -9 (U) | 2 | 19 | 317 | 310 | 61.5 | 0.0 | ||
| 5 | | Bills | 12/1/2022 | 1-0 | -204 | @ | +170 | W 24-10 | -4 | +10 (Y) | 43.5 | -9.5 (U) | 3 | 22 | 355 | 242 | 60.0 | |||
| 6 | | Bills | 9/11/2023 | 0-1 | -137 | @ | +116 | L 16-22 | -2.5 | -8.5 (N) | 44.5 | -6.5 (U) | 1 | 19 | 314 | 289 | 38.5 | |||
| 7 | | Bills | 10/22/2023 | 0-1 | -402 | @ | +313 | L 25-29 | -7.5 | -11.5 (N) | 41 | +13 (O) | 3 | 24 | 339 | 364 | 41.7 | 66.7 | ||
| 8 | | Bills | 11/5/2023 | 0-1 | +107 | @ | -128 | L 18-24 | +1.5 | -4.5 (N) | 51 | -9 (U) | 2 | 21 | 317 | 397 | 58.3 | |||
| 9 | | Bills | 12/10/2023 | 1-0 | +106 | @ | -126 | W 20-17 | +2 | +5 (Y) | 49.5 | -12.5 (U) | 2 | 21 | 327 | 346 | 40.0 | 100.0 | ||
| 10 | | Bills | 12/23/2023 | 0-1 | -796 | @ | +550 | W 24-22 | -12.5 | -10.5 (N) | 44.5 | +1.5 (O) | 3 | 16 | 335 | 273 | 50.0 | |||
| 11 | | Bills | 1/7/2024 | 1-0 | -149 | @ | +126 | W 21-14 | -2.5 | +4.5 (Y) | 48 | -13 (U) | 3 | 26 | 473 | 275 | 60.0 | 33.3 | ||
| 12 | | Bills | 9/12/2024 | 1-0 | +117 | @ | -138 | W 31-10 | +2.5 | +23.5 (Y) | 49 | -8 (U) | 4 | 13 | 247 | 351 | 33.3 | 100.0 | ||
| 13 | | Bills | 9/29/2024 | 0-1 | +122 | @ | -146 | L 10-35 | +2.5 | -22.5 (N) | 47.5 | -2.5 (U) | 1 | 12 | 236 | 427 | 23.1 | 100.0 | ||
| 14 | | Bills | 10/6/2024 | 0-1 | +103 | @ | -122 | L 20-23 | +1.5 | -1.5 (N) | 48 | -5 (U) | 2 | 16 | 276 | 425 | 21.4 | 100.0 | ||
| 15 | | Bills | 10/14/2024 | 1-0 | -121 | @ | +101 | W 23-20 | -1.5 | +1.5 (Y) | 41.5 | +1.5 (O) | 3 | 24 | 359 | 393 | 45.5 | |||
| 16 | | Bills | 11/10/2024 | 1-0 | -227 | @ | +187 | W 30-20 | -4.5 | +5.5 (Y) | 46.5 | +3.5 (O) | 3 | 21 | 415 | 361 | 50.0 | 66.7 | ||
| 17 | | Bills | 1/5/2025 | 0-1 | -173 | @ | +145 | L 16-23 | -3 | -10 (N) | 36.5 | +2.5 (O) | 2 | 16 | 259 | 309 | 40.0 | 25.0 | ||
| 18 | | Bills | 1/26/2025 | 0-1 | +100 | @ | -116 | L 29-32 | +1.5 | -1.5 (N) | 49.5 | +11.5 (O) | 4 | 22 | 374 | 368 | 35.7 | 66.7 | ||
| 19 | | Bills | 9/14/2025 | 1-0 | -283 | @ | +230 | W 30-10 | -6 | +14 (Y) | 47.5 | -7.5 (U) | 3 | 25 | 403 | 154 | 35.7 | 100.0 | ||
| 20 | | Bills | 11/9/2025 | 0-1 | -455 | @ | +350 | L 13-30 | -7.5 | -24.5 (N) | 50 | -7 (U) | 2 | 20 | 376 | 370 | 33.3 | 50.0 | ||
| 21 | | Bills | 11/20/2025 | 0-1 | -235 | @ | +193 | L 19-23 | -4.5 | -8.5 (N) | 44 | -2 (U) | 2 | 14 | 326 | 261 | 31.3 | 60.0 | ||
| 22 | | Bills | 11/30/2025 | 1-0 | -175 | @ | +145 | W 26-7 | -3 | +16 (Y) | 44.5 | -11.5 (U) | 3 | 26 | 372 | 166 | 53.3 | 100.0 | ||
| 23 | | Bills | 12/14/2025 | 1-0 | -139 | @ | +119 | W 35-31 | -2.5 | +1.5 (Y) | 49.5 | +16.5 (O) | 5 | 22 | 349 | 385 | 57.1 | 100.0 | ||
| 24 | | Bills | 12/21/2025 | 0-1 | -599 | @ | +442 | W 23-20 | -10.5 | -7.5 (N) | 41.5 | +1.5 (O) | 3 | 16 | 259 | 294 | 25.0 | 0.0 | ||
| 25 | | Bills | 1/11/2026 | 1-0 | +106 | @ | -126 | W 27-24 | +1.5 | +4.5 (Y) | 51.5 | -0.5 (U) | 3 | 20 | 340 | 359 | 50.0 | 100.0 | ||
| Average | 1.6 | 2.7 | 20.8 | 351.6 | 323.9 | 44.5 | 0.0 | |||||||||||||
| Total | 12-15 | 73 | 562 | 9,492 | 8,744 | 44.5 | 61.2 | |||||||||||||
BUF
MIA
BAL
KC
NYJ
NE
CIN
LAC
HOU
NYJ
IND
PIT
CLE
JAXStatMuse has team, game-level data for spread records going back to the 1979 season.
More NFL News
The 49ers open the practice window for WR Christian Kirk
Broncos cornerback Riley Moss active for game against Seahawks
Dolphins have been competitive despite 0-5 start but aim for better execution after bye
Jon Morris, former AFL and NFL center with Patriots, dies at 84
Lions hope to keep momentum after bye week, hosting Packers and Vikings in next 2 games
Jayden Daniels and the Commanders try to put disheartening tie behind them as unbeaten 49ers loom
More Bills Stats
Team Leaders 
PASS
1,249
Allen
RUSH
532
Cook
REC
277
Kincaid
Team Rankings
PPG
32.8
1st
OPP PPG
28.2
28th
RUSH YDS/G
158.0
5th
PASS YDS/G
249.8
12th
LV
MIN
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 1 | .700 | |
2 | 3 | 0 | .400 | |
2 | 3 | 0 | .400 | |
1 | 3 | 1 | .300 | |
| NFC North | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| NFC South | W | L | T | PCT |
2 | 2 | 0 | .500 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
1 | 4 | 0 | .200 | |
| NFC West | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 3 | 0 | .500 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 |
Giants
Eagles
Cowboys
Commanders
Packers
Lions
Bears
Panthers
Falcons
Buccaneers
Saints
49ers
Seahawks
Rams
Cardinals| AFC East | W | L | T | PCT |
|---|---|---|---|---|
4 | 1 | 0 | .800 | |
3 | 2 | 0 | .600 | |
2 | 3 | 0 | .400 | |
0 | 5 | 0 | .000 | |
| AFC North | W | L | T | PCT |
4 | 1 | 0 | .800 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| AFC South | W | L | T | PCT |
4 | 1 | 0 | .800 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
0 | 5 | 0 | .000 | |
| AFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
4 | 2 | 0 | .667 | |
3 | 2 | 0 | .600 | |
0 | 5 | 0 | .000 |
Titans
Broncos