The Buffalo Bills have a 25-28 record in the regular season and playoffs against the AFC South since September 11, 2001.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 10/13/2002 | 1-0 | @ | W 31-24 | 1.000 | 4 | 25 | 403 | 338 | 42.9 | |||
| 2 | | Bills | 9/14/2003 | 1-0 | @ | W 38-17 | 1.000 | 5 | 20 | 371 | 287 | 57.1 | 50.0 | ||
| 3 | | Bills | 11/16/2003 | 0-1 | vs | L 10-12 | .000 | 0 | 17 | 335 | 245 | 23.1 | |||
| 4 | | Bills | 11/23/2003 | 0-1 | vs | L 14-17 | .000 | 2 | 16 | 228 | 326 | 23.1 | 100.0 | ||
| 5 | | Bills | 12/14/2003 | 0-1 | @ | L 26-28 | .000 | 3 | 13 | 241 | 349 | 16.7 | 100.0 | ||
| 6 | | Bills | 9/12/2004 | 0-1 | vs | L 10-13 | .000 | 1 | 16 | 242 | 225 | 50.0 | |||
| 7 | | Bills | 9/11/2005 | 1-0 | vs | W 22-7 | 1.000 | 1 | 20 | 316 | 120 | 21.4 | 100.0 | ||
| 8 | | Bills | 11/12/2006 | 0-1 | @ | L 16-17 | .000 | 1 | 10 | 162 | 384 | 35.7 | 100.0 | ||
| 9 | | Bills | 11/19/2006 | 1-0 | @ | W 24-21 | 1.000 | 3 | 17 | 403 | 394 | 28.6 | 100.0 | ||
| 10 | | Bills | 11/26/2006 | 1-0 | vs | W 27-24 | 1.000 | 3 | 13 | 241 | 323 | 30.0 | |||
| 11 | | Bills | 12/24/2006 | 0-1 | vs | L 29-30 | .000 | 2 | 22 | 368 | 396 | 20.0 | 50.0 | ||
| 12 | | Bills | 11/25/2007 | 0-1 | @ | L 14-36 | .000 | 2 | 20 | 297 | 416 | 56.3 | 50.0 | ||
| 13 | | Bills | 9/14/2008 | 1-0 | @ | W 20-16 | 1.000 | 2 | 18 | 285 | 243 | 54.5 | |||
| 14 | | Bills | 11/1/2009 | 0-1 | vs | L 10-31 | .000 | 1 | 9 | 204 | 439 | 20.0 | 0.0 | ||
| 15 | | Bills | 11/15/2009 | 0-1 | @ | L 17-41 | .000 | 2 | 14 | 296 | 378 | 35.7 | 0.0 | ||
| 16 | | Bills | 11/22/2009 | 0-1 | @ | L 15-18 | .000 | 1 | 14 | 343 | 310 | 27.3 | 0.0 | ||
| 17 | | Bills | 1/3/2010 | 1-0 | vs | W 30-7 | 1.000 | 3 | 19 | 403 | 157 | 35.7 | |||
| 18 | | Bills | 10/10/2010 | 0-1 | vs | L 26-36 | .000 | 3 | 17 | 306 | 381 | 27.3 | 0.0 | ||
| 19 | | Bills | 12/4/2011 | 0-1 | vs | L 17-23 | .000 | 2 | 18 | 386 | 317 | 43.8 | 50.0 | ||
| 20 | | Bills | 10/21/2012 | 0-1 | vs | L 34-35 | .000 | 4 | 22 | 382 | 390 | 58.3 | 0.0 | ||
| 21 | | Bills | 11/4/2012 | 0-1 | @ | L 9-21 | .000 | 0 | 17 | 304 | 374 | 18.2 | 100.0 | ||
| 22 | | Bills | 11/25/2012 | 0-1 | @ | L 13-20 | .000 | 1 | 16 | 304 | 312 | 30.8 | |||
| 23 | | Bills | 12/2/2012 | 1-0 | vs | W 34-18 | 1.000 | 4 | 20 | 344 | 236 | 41.7 | 0.0 | ||
| 24 | | Bills | 12/15/2013 | 1-0 | @ | W 27-20 | 1.000 | 3 | 25 | 366 | 354 | 38.5 | |||
| 25 | | Bills | 9/28/2014 | 0-1 | @ | L 17-23 | .000 | 2 | 17 | 316 | 301 | 31.3 | |||
| Average | .472 | 2.4 | 18.3 | 329.4 | 313.7 | 38.5 | 0.0 | ||||||||
| Total | 25-28 | .472 | 127 | 968 | 17,459 | 16,628 | 38.5 | 53.4 | |||||||
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More Bills Stats
Team Leaders 
PASS
334
Allen
RUSH
57
Cook
REC
130
Kincaid
Team Rankings
PPG
36.0
5th
OPP PPG
31.0
22nd
RUSH YDS/G
86.0
24th
PASS YDS/G
334.0
4th
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| NFC East | W | L | T | PCT |
|---|---|---|---|---|
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
| NFC North | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
| NFC South | W | L | T | PCT |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
| NFC West | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 |
Giants
Eagles
Commanders
Cowboys
Vikings
Bears
Packers
Falcons
Buccaneers
Saints
Panthers
49ers
Cardinals
Seahawks| AFC East | W | L | T | PCT |
|---|---|---|---|---|
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
| AFC North | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
| AFC South | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
| AFC West | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
0 | 0 | 0 | ||
0 | 0 | 0 | ||
0 | 1 | 0 | .000 |
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