The Arizona Cardinals had a 2-3 record against the Bills between November 6, 1976 and April 24, 2004.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Cardinals | 11/15/1981 | 1-0 |  STL | vs |  BUF | W 24-0 | 1.000 | 3 | 22 | 338 | 311 | ||
| 2 | | Cardinals | 9/9/1984 | 1-0 | STL | vs | BUF | W 37-7 | 1.000 | 4 | 28 | 486 | 171 | ||
| 3 | | Cardinals | 9/21/1986 | 0-1 | STL | @ | BUF | L 10-17 | .000 | 1 | 25 | 381 | 176 | ||
| 4 |  | Cardinals | 11/11/1990 | 0-1 |  PHX | @ | BUF | L 14-45 | .000 | 2 | 11 | 127 | 360 | ||
| 5 |  | Cardinals | 12/19/1999 | 0-1 |  ARI | vs | BUF | L 21-31 | .000 | 3 | 14 | 178 | 376 | 36.4 | 0.0 |
| Average | .400 | 2.6 | 20.0 | 302.0 | 278.8 | ||||||||||
| Total | 2-3 | .400 | 13 | 100 | 1,510 | 1,394 |
More Cardinals Stats
Team Rankings
PPG
20.6
23rd
OPP PPG
19.2
4th
RUSH YDS/G
118.2
13th
PASS YDS/G
192.4
30th
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NFL 2025 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 4 | 2 | 0 | .667 |
 Commanders | 3 | 2 | 0 | .600 |
| NFC North | W | L | T | PCT |
 Lions | 4 | 1 | 0 | .800 |
 Packers | 2 | 1 | 1 | .625 |
| NFC South | W | L | T | PCT |
 Buccaneers | 4 | 1 | 0 | .800 |
 Falcons | 2 | 2 | 0 | .500 |
| NFC West | W | L | T | PCT |
 49ers | 4 | 1 | 0 | .800 |
 Seahawks | 3 | 2 | 0 | .600 |
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