21 teams are tied for the highest point differential per game played in a loss, with -1. The first three are the Buffalo Bills on December 28, the Los Angeles Rams on December 18 and the Tampa Bay Buccaneers on December 11.
Interpreted as:
highest point differential per game by a team a, regular-season l time| TEAM | DIFF/GP | L | DIFF | GP | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | -1 | 1 | -1 | 1 | 12/28/2025 | vs | L 12-13 | 2 | 20 | 331 | 190 | 40.0 | 66.7 | ||
| 2 |  | Rams | -1 | 1 | -1 | 1 | 12/18/2025 | @ | L 37-38 | 4 | 26 | 581 | 415 | 40.0 | 66.7 | ||
| 3 |  | Buccaneers | -1 | 1 | -1 | 1 | 12/11/2025 | vs | L 28-29 | 3 | 28 | 338 | 476 | 44.4 | |||
| 4 |  | Commanders | -1 | 1 | -1 | 1 | 11/30/2025 | vs | L 26-27 | 3 | 30 | 419 | 402 | 47.1 | 100.0 | ||
| 5 |  | Falcons | -1 | 1 | -1 | 1 | 11/2/2025 | @ | L 23-24 | 3 | 17 | 288 | 331 | 10.0 | 66.7 | ||
| 6 |  | Raiders | -1 | 1 | -1 | 1 | 11/2/2025 | vs | L 29-30 | 4 | 26 | 331 | 367 | 70.0 | 0.0 | ||
| 7 |  | Bengals | -1 | 1 | -1 | 1 | 10/26/2025 | vs | L 38-39 | 5 | 24 | 398 | 502 | 44.4 | 0.0 | ||
| 8 |  | Giants | -1 | 1 | -1 | 1 | 10/19/2025 | @ | L 32-33 | 5 | 26 | 387 | 407 | 40.0 | 100.0 | ||
| 9 | | Commanders | -1 | 1 | -1 | 1 | 10/13/2025 | vs | L 24-25 | 3 | 22 | 329 | 386 | 37.5 | 100.0 | ||
| 10 |  | Cardinals | -1 | 1 | -1 | 1 | 10/5/2025 | vs | L 21-22 | 3 | 16 | 360 | 327 | 43.8 | |||
| 11 | | Raiders | -1 | 1 | -1 | 1 | 9/28/2025 | vs | L 24-25 | 3 | 17 | 357 | 271 | 25.0 | 0.0 | ||
| 12 | | Cardinals | -1 | 1 | -1 | 1 | 9/21/2025 | @ | L 15-16 | 1 | 16 | 260 | 355 | 33.3 | 100.0 | ||
| 13 |  | Texans | -1 | 1 | -1 | 1 | 9/15/2025 | vs | L 19-20 | 2 | 12 | 266 | 360 | 22.2 | 0.0 | ||
| 14 |  | Broncos | -1 | 1 | -1 | 1 | 9/14/2025 | @ | L 28-29 | 4 | 23 | 324 | 473 | 44.4 | |||
| 15 |  | Browns | -1 | 1 | -1 | 1 | 9/7/2025 | vs | L 16-17 | 2 | 22 | 327 | 141 | 56.3 | 66.7 | ||
| 16 |  | Ravens | -1 | 1 | -1 | 1 | 9/7/2025 | @ | L 40-41 | 5 | 19 | 432 | 497 | 54.5 | |||
| 17 |  | Saints | -1 | 1 | -1 | 1 | 12/15/2024 | vs | L 19-20 | 2 | 17 | 245 | 326 | 27.3 | 100.0 | ||
| 18 |  | Patriots | -1 | 1 | -1 | 1 | 12/1/2024 | vs | L 24-25 | 2 | 23 | 422 | 253 | 54.5 | |||
| 19 | | Cardinals | -1 | 1 | -1 | 1 | 12/1/2024 | @ | L 22-23 | 1 | 25 | 406 | 273 | 38.5 | 0.0 | ||
| 20 |  | Bears | -1 | 1 | -1 | 1 | 11/17/2024 | vs | L 19-20 | 2 | 23 | 391 | 366 | 56.3 | 100.0 | ||
| 21 |  | Jets | -1 | 1 | -1 | 1 | 11/17/2024 | vs | L 27-28 | 3 | 10 | 253 | 332 | 30.8 | 0.0 | ||
| 22 | | Commanders | -1 | 1 | -1 | 1 | 11/10/2024 | vs | L 27-28 | 3 | 19 | 242 | 312 | 35.7 | 0.0 | ||
| 23 | | Bengals | -1 | 1 | -1 | 1 | 11/7/2024 | @ | L 34-35 | 5 | 27 | 470 | 389 | 50.0 | 50.0 | ||
| 24 | | Saints | -1 | 1 | -1 | 1 | 11/3/2024 | @ | L 22-23 | 2 | 25 | 427 | 246 | 33.3 | 66.7 | ||
| 25 |  | Dolphins | -1 | 1 | -1 | 1 | 10/27/2024 | vs | L 27-28 | 3 | 22 | 377 | 389 | 73.3 | |||
More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
