O.J. Simpson has the most games for the Bills with 100+ rushing yards in a season, with 11 games in 1973.
| NAME | GP | RUSH YDS | SEASON | TM | ATT | YPC | RUSH YDS/G | RUSH TD | REC YDS | REC | TRG | AVG | REC YDS/G | REC TD | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | O.J. Simpson | 11 | 1,770 | 1973 |  BUF | 278 | 6.4 | 160.9 | 11 | 70 | 6 | 11.7 | 6.4 | 0 | |
| 2 |  | T. Thomas | 9 | 1,076 | 1992 | BUF | 200 | 5.4 | 119.6 | 8 | 274 | 26 | 10.5 | 30.4 | 2 | |
| 3 | | T. Thomas | 8 | 997 | 1991 | BUF | 187 | 5.3 | 124.6 | 7 | 349 | 27 | 12.9 | 43.6 | 2 | |
| 4 | | O.J. Simpson | 8 | 1,328 | 1975 | BUF | 209 | 6.4 | 166.0 | 10 | 139 | 9 | 15.4 | 17.4 | 2 | |
| 5 |  | J. Cook III | 7 | 947 | 2025 | BUF | 157 | 6.0 | 135.3 | 7 | 88 | 14 | 15 | 6.3 | 12.6 | 0 |
| 6 |  | L. McCoy | 7 | 914 | 2016 | BUF | 133 | 6.9 | 130.6 | 10 | 141 | 23 | 26 | 6.1 | 20.1 | 0 |
| 7 | | W. McGahee | 7 | 768 | 2004 | BUF | 183 | 4.2 | 109.7 | 11 | 130 | 14 | 24 | 9.3 | 18.6 | 0 |
| 8 | | T. Thomas | 7 | 819 | 1993 | BUF | 188 | 4.4 | 117.0 | 2 | 172 | 21 | 8.2 | 24.6 | 0 | |
| 9 | | O.J. Simpson | 7 | 1,171 | 1976 | BUF | 184 | 6.4 | 167.3 | 8 | 67 | 7 | 9.6 | 9.6 | 0 | |
| 10 | | F. Jackson | 6 | 695 | 2011 | BUF | 116 | 6.0 | 115.8 | 4 | 235 | 21 | 23 | 11.2 | 39.2 | 0 |
| 11 | | T. Henry | 6 | 861 | 2002 | BUF | 162 | 5.3 | 143.5 | 8 | 110 | 15 | 26 | 7.3 | 18.3 | 0 |
| 12 | | O.J. Simpson | 6 | 791 | 1972 | BUF | 154 | 5.1 | 131.8 | 3 | 59 | 11 | 5.4 | 9.8 | 0 | |
| 13 | | C. Gilchrist | 6 | 751 | 1962 | BUF | 118 | 6.4 | 125.2 | 7 | 73 | 8 | 9.1 | 12.2 | 2 | |
| 14 | | C.J. Spiller | 5 | 640 | 2012 | BUF | 82 | 7.8 | 128.0 | 4 | 101 | 13 | 19 | 7.8 | 20.2 | 0 |
| 15 | | W. McGahee | 5 | 649 | 2005 | BUF | 131 | 5.0 | 129.8 | 2 | 82 | 10 | 13 | 8.2 | 16.4 | 0 |
| 16 | | T. Henry | 5 | 722 | 2003 | BUF | 134 | 5.4 | 144.4 | 4 | 29 | 6 | 9 | 4.8 | 5.8 | 0 |
| 17 | | T. Thomas | 5 | 781 | 1990 | BUF | 118 | 6.6 | 156.2 | 4 | 48 | 7 | 6.9 | 9.6 | 0 | |
| 18 | | T. Thomas | 5 | 585 | 1989 | BUF | 127 | 4.6 | 117.0 | 2 | 238 | 20 | 11.9 | 47.6 | 3 | |
| 19 | | J. Cook III | 4 | 423 | 2024 | BUF | 56 | 7.6 | 105.8 | 6 | 89 | 8 | 8 | 11.1 | 22.3 | 1 |
| 20 | | L. McCoy | 4 | 531 | 2017 | BUF | 94 | 5.6 | 132.8 | 3 | 83 | 12 | 14 | 6.9 | 20.8 | 1 |
| 21 | | C.J. Spiller | 4 | 473 | 2013 | BUF | 62 | 7.6 | 118.3 | 1 | 89 | 12 | 16 | 7.4 | 22.3 | 0 |
| 22 | | T. Thomas | 4 | 446 | 1994 | BUF | 102 | 4.4 | 111.5 | 4 | 55 | 8 | 6.9 | 13.8 | 1 | |
| 23 | | J. Cribbs | 4 | 556 | 1983 | BUF | 92 | 6.0 | 139.0 | 1 | 96 | 10 | 9.6 | 24.0 | 1 | |
| 24 | | O.J. Simpson | 4 | 481 | 1974 | BUF | 108 | 4.5 | 120.3 | 2 | 37 | 2 | 18.5 | 9.3 | 1 | |
| 25 | | J. Cook III | 3 | 411 | 2023 | BUF | 54 | 7.6 | 137.0 | 1 | 89 | 8 | 9 | 11.1 | 29.7 | 1 |
StatMuse has game-level data for rushing yards going back to the 1960 season.
More Bills Stats
Team Rankings
PPG
28.1
5th
OPP PPG
21.6
13th
RUSH YDS/G
155.7
1st
PASS YDS/G
240.5
11th
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