5 players were tied for the most games with 250+ yards and 2+ touchdowns, with 3 games. The first three are Marshall Faulk, O.J. Simpson and Gale Sayers.

Interpreted as:

most regular-season games by a player with 250+ yards and 2+ tds

	NAME	GP	YDS	TD	YDS/G	RUSH YDS	RUSH YDS/G	RUSH TD	REC YDS	REC YDS/G	REC TD	KR YDS	KR YDS/G	KR TD	PR YDS	PR YDS/G	PR TD
1	Marshall Faulk M. Faulk	3	780	7		614	204.7	5	166	55.3	2	0	0.0	0	0	0.0	0
2	O.J. Simpson	3	826	6		622	207.3	5	63	21.0	0	141	47.0	1	0	0.0	0
3	Gale Sayers G. Sayers	3	972	12		374	124.7	6	178	59.3	3	286	95.3	2	134	44.7	1
4	Timmy Brown T. Brown	3	879	6		204	68.0	0	309	103.0	4	362	120.7	2	4	1.3	0
5	Jim Brown J. Brown	3	833	11		636	212.0	10	173	57.7	1			0			0
6	Ja'Marr Chase J. Chase	2	530	6	265.0	0	0.0	0	530	265.0	6	0	0.0	0	0	0.0	0
7	Jonathan Taylor J. Taylor	2	540	5	270.0	497	248.5	5	43	21.5	0	0	0.0	0	0	0.0	0
8	Derrick Henry D. Henry	2	514	4	257.0	462	231.0	4	52	26.0	0	0	0.0	0	0	0.0	0
9	Saquon Barkley S. Barkley	2	581	4	290.5	444	222.0	3	137	68.5	1	0	0.0	0	0	0.0	0
10	Tyreek Hill T. Hill	2	537	6	268.5	4	2.0	0	438	219.0	5	0	0.0	0	95	47.5	1
11	Ted Ginn T. Ginn	2	567	4		0	0.0	0	0	0.0	0	475	237.5	3	92	46.0	1
12	Leon Washington L. Washington	2	527	4		67	33.5	1	34	17.0	1	355	177.5	2	71	35.5	0
13	Adrian Peterson A. Peterson	2	676	6		520	260.0	6	28	14.0	0	128	64.0	0	0	0.0	0
14	Maurice Jones-Drew M. Jones-Drew	2	563	5		291	145.5	4	74	37.0	0	185	92.5	1	13	6.5	0
15	Dante Hall D. Hall	2	538	4		0	0.0	0	188	94.0	3	334	167.0	1	16	8.0	0
16	LaDainian Tomlinson L. Tomlinson	2	531	5		463	231.5	5	68	34.0	0	0	0.0	0	0	0.0	0
17	Priest Holmes P. Holmes	2	584	5		365	182.5	3	219	109.5	2	0	0.0	0	0	0.0	0
18	Corey Dillon C. Dillon	2	554	6		524	262.0	6	30	15.0	0	0	0.0	0	0	0.0	0
19	Lionel James L. James	2	661	4		178	89.0	2	286	143.0	2	173	86.5	0	24	12.0	0
20	Travis Williams T. Williams	2	567	5		121	60.5	2	85	42.5	1	278	139.0	1	83	41.5	1
21	Gary Ballman G. Ballman	2	600	4		0	0.0	0	289	144.5	3	311	155.5	1	0	0.0	0
22	Jahmyr Gibbs J. Gibbs	1	264	3	264.0	219	219.0	2	45	45.0	1	0	0.0	0	0	0.0	0
23	Justice Hill J. Hill	1	250	2	250.0	76	76.0	1	41	41.0	1	133	133.0	0	0	0.0	0
24	Amari Cooper A. Cooper	1	265	2	265.0	0	0.0	0	265	265.0	2	0	0.0	0	0	0.0	0
25	Josh Jacobs J. Jacobs	1	303	2	303.0	229	229.0	2	74	74.0	0	0	0.0	0	0	0.0	0

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Bills - w	12	5	0	.706
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Ravens - e	8	9	0	.471
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Cardinals - e	3	14	0	.176