Jamaal Charles has collected the most PPR fantasy points in a game, with 59.5 points versus the Oakland Raiders on December 15, 2013.

most ppr points by a player in a single regular-season game, all-time

NAME	DATE	TM		OPP	FPTS (PPR)	YDS	TD	RUSH YDS	RUSH TD	REC YDS	REC TD	KR YDS	PR YDS
Jamaal Charles	12/15/2013	KC	@	OAK	59.5	215	5	20	1	195	4	0	0
Tyreek Hill	11/29/2020	KC	@	TB	57.9	269	3	0	0	269	3	0	0
Clinton Portis	12/7/2003	DEN	vs	KC	57.4	254	5	218	5	36	0	0	0
Alvin Kamara	12/25/2020	NO	vs	MIN	56.2	172	6	155	6	17	0	0	0
Ja'Marr Chase	1/2/2022	CIN	vs	KC	55.6	266	3	0	0	266	3	0	0
Chris Johnson	9/20/2009	TEN	vs	HOU	55.4	284	3	197	2	87	1	0	0
Doug Martin	11/4/2012	TB	@	OAK	55.2	272	4	251	4	21	0	0	0
Will Fuller	10/6/2019	HOU	vs	ATL	53.7	217	3	0	0	217	3	0	0
Jonathan Taylor	11/21/2021	IND	@	BUF	53.4	204	5	185	4	19	1	0	0
Drew Bennett	12/13/2004	TEN	vs	KC	53.3	233	3	0	0	233	3	0	0
Tyler Lockett	10/25/2020	SEA	@	ARI	53	209	3	0	0	200	3	9	0
Brandon Marshall	12/13/2009	DEN	@	IND	53	200	2	0	0	200	2	0	0
Le'Veon Bell	12/11/2016	PIT	@	BUF	51.8	298	3	236	3	62	0	0	0
Wes Welker	9/25/2011	NE	@	BUF	51.6	236	2	19	0	217	2	0	0
Kevin Curtis	9/23/2007	PHI	vs	DET	51.1	221	3	0	0	221	3	0	0
Calvin Johnson	10/27/2013	DET	vs	DAL	50.9	329	1	0	0	329	1	0	0
Julio Jones	11/26/2017	ATL	vs	TB	50.8	268	2	15	0	253	2	0	0
Jahvid Best	9/19/2010	DET	vs	PHI	50.2	232	3	78	2	154	1	0	0
Andre Johnson	11/3/2013	HOU	vs	IND	49.9	229	3	0	0	229	3	0	0
Jerome Harrison	12/20/2009	CLE	@	KC	49.8	298	3	286	3	12	0	0	0
Reggie Bush	12/3/2006	NO	vs	SF	49.8	172	4	37	3	131	1	0	4
Amari Cooper	12/9/2018	DAL	vs	PHI	49.7	217	3	0	0	217	3	0	0
Todd Gurley	12/24/2017	LAR	@	TEN	49.6	276	2	118	0	158	2	0	0
Lee Evans	11/19/2006	BUF	@	HOU	49.5	265	2	0	0	265	2	0	0
Eric Decker	12/1/2013	DEN	@	KC	49.4	174	4	0	0	174	4	0	0